CAS 89105-94-2|Fibrinogen-Binding Inhibitor Peptide

Introduction：Basic information about CAS 89105-94-2|Fibrinogen-Binding Inhibitor Peptide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameFibrinogen-Binding Inhibitor Peptide
CAS Number89105-94-2Molecular Weight1189.28000
Density1.342g/cm3Boiling Point1809.886ºC at 760 mmHg
Molecular FormulaC50H80N18O16Melting Point/
MSDS/Flash Point1048.381ºC

Names

NameFibrinogen Binding Inhibitor Peptide
SynonymMore Synonyms

Fibrinogen-Binding Inhibitor Peptide BiologicalActivity

DescriptionFibrinogen Binding Inhibitor Peptide is a dodecapeptide (HHLGGAKQAGDV, H12), which is a fibrinogen γ-chain carboxy-terminal sequence (γ400-411). Fibrinogen Binding Inhibitor Peptide is a specific binding site of the ligand for activated glycoprotein (GP) IIb/IIIa.
Related CatalogSignaling Pathways >>Others >>OthersPeptidesResearch Areas >>Cardiovascular Disease
In VitroGlycoprotein (GP) IIb/IIIa, which exists on the membrane of platelets, changes its form from inactive to active when platelets adhere to collagen exposed on sites of vascular injury. In the circulation, platelet aggregation is mediated by fibrinogen by bridging adjacent platelets through GPIIb/IIIa in an activation-dependent manner. A dodecapeptide HHLGGAKQAGDV (H12), corresponding to the fibrinogen γ-chain carboxy-terminal sequence (γ400-411), is a specific binding site of the ligand for activated GPIIb/IIIa[1].
References

[1]. Okamura Y, et al. Release abilities of adenosine diphosphate from phospholipid vesicles with different membraneproperties and their hemostatic effects as a platelet substitute. J Control Release. 2010 Dec 20;148(3):373-9.

Chemical & Physical Properties

Density1.342g/cm3
Boiling Point1809.886ºC at 760 mmHg
Molecular FormulaC50H80N18O16
Molecular Weight1189.28000
Flash Point1048.381ºC
Exact Mass1188.60000
PSA547.19000
InChIKeySTSKWZSBFZRSGP-GYDGUXFESA-N
SMILESCC(C)CC(NC(=O)C(Cc1cnc[nH]1)NC(=O)C(N)Cc1cnc[nH]1)C(=O)NCC(=O)NCC(=O)NC(C)C(=O)NC(CCCCN)C(=O)NC(CCC(N)=O)C(=O)NC(C)C(=O)NCC(=O)NC(CC(=O)O)C(=O)NC(C(=O)O)C(C)C
Storage condition2-8℃

Synonyms

MFCD00167528
FIBRINOGEN-BINDING INHIBITOR PEPTIDE
H-HIS-HIS-LEU-GLY-GLY-ALA-LYS-GLN-ALA-GLY-ASP-VAL-OH
Fibrinogen Binding Inhibitory Peptide
HHLGGAKQAGDV
HIS-HIS-LEU-GLY-GLY-ALA-LYS-GLN-ALA-GLY-ASP-VAL
FIBRINOGEN Y-CHAIN DODECAPETIDE
FIBRINOGEN-BINDING INHIBITOR PEPTIDE
Fibrinogen Binding Inhibitor Peptide
CAS 80755-86-8|GQQHHLGGAKQAGDV
CAS 125455-58-5|H-Gly-Arg-Ala-Asp-Ser-Pro-Lys-OH acetate salt
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