Introduction：Basic information about CAS 5122-36-1|FAPy-adenine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | FAPy-adenine |
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| CAS Number | 5122-36-1 | Molecular Weight | 281.266 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 464.7±47.0 °C at 760 mmHg |
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| Molecular Formula | C5H7N5O | Melting Point | / |
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| MSDS | / | Flash Point | 234.8±29.3 °C |
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Names
| Name | 4,6-diamino-5-formamidopyrimidine |
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| Synonym | More Synonyms |
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FAPy-adenine BiologicalActivity
| Description | FAPy-adenine is an oxidized DNA base. Fapy-adenine shows an increased trend levels in the Alzheimer's disease brain. Oxidized nucleosides are biochemical markers for tumors, aging, and neurodegenerative diseases[1][2][3]. |
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| Related Catalog | Research Areas >>CancerResearch Areas >>Neurological Disease |
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| Target | Human Endogenous Metabolite |
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| In Vitro | In the absence of the external field the FAPy-adenine is able to form pairs with all four canonical nucleic acid bases. In contrast, in the presence of the external field the mispairing abilities of FAPy-adenine become insignificant since the most stable dimers are formed with thymine[1]. |
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| In Vivo | The nuclear DNA damage by oxygen-derived radicals is increased in Alzheimer's disease and support the concept that the brain is under increased oxidative stress in Alzheimer's disease[1]. |
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| References | [1]. Gabbita SP, et al. Increased nuclear DNA oxidation in the brain in Alzheimer's disease. [2]. Cysewski P, et al. Theoretical description of the coding potential of diamino-5-formamidopyrimidines. Z Naturforsch C J Biosci. 1999 Mar-Apr;54(3-4):239-45. [3]. Lee SH, et al. A rapid and sensitive method for quantitation of nucleosides in human urine using liquid chromatography/mass spectrometry with direct urine injection. Rapid Commun Mass Spectrom. 2004;18(9):973-7. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 464.7±47.0 °C at 760 mmHg |
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| Molecular Formula | C5H7N5O |
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| Molecular Weight | 281.266 |
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| Flash Point | 234.8±29.3 °C |
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| Exact Mass | 281.080048 |
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| PSA | 106.92000 |
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| LogP | 1.92 |
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| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
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| Index of Refraction | 1.674 |
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| InChIKey | MVYUVUOSXNYQLL-UHFFFAOYSA-N |
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| SMILES | Nc1ncnc(N)c1NC=O |
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Safety Information
Customs
| HS Code | 2933599090 |
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| Summary | 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Fapyade |
| FAPy |
| 3H-Pyrazol-3-one, 2,4-dihydro-2-(4-nitrophenyl)-5-phenyl- |
| N-(4,6-diaminopyrimidin-5-yl)formamide |
| 4,6-Diamino-5-formamidopyrimidine |
| 4,6-Diamino-5-N-formamidopyrimidine |
| 2-(4-Nitrophenyl)-5-phenyl-2,4-dihydro-3H-pyrazol-3-one |
| 4,6-Diamino-5-pyrimidinylformamide |
