Introduction：Basic information about CAS 104375-88-4|5'-DMT-5-I-2'-dU, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 5'-DMT-5-I-2'-dU |
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| CAS Number | 104375-88-4 | Molecular Weight | 656.46 |
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| Density | 1.60±0.1 g/cm3(Predicted) | Boiling Point | / |
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| Molecular Formula | C30H29IN2O7 | Melting Point | >128 °C (decomp) |
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| MSDS | / | Flash Point | / |
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Names
| Name | 1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-5-iodopyrimidine-2,4-dione |
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| Synonym | More Synonyms |
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5'-DMT-5-I-2'-dU BiologicalActivity
| Description | 5’-O-DMTr-5-iodo-2’-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>Nucleoside Antimetabolite/Analog |
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| References | [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. |
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Chemical & Physical Properties
| Density | 1.60±0.1 g/cm3(Predicted) |
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| Melting Point | >128 °C (decomp) |
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| Molecular Formula | C30H29IN2O7 |
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| Molecular Weight | 656.46 |
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| Exact Mass | 656.10200 |
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| PSA | 112.01000 |
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| LogP | 3.81550 |
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| InChIKey | RLDUYGSOCGOJTP-OYUWMTPXSA-N |
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| SMILES | COc1ccc(C(OCC2OC(n3cc(I)c(=O)[nH]c3=O)CC2O)(c2ccccc2)c2ccc(OC)cc2)cc1 |
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| Storage condition | 2-8℃ |
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Synonyms
| 5'-O-DMTr-IUdR |
| 5-iodo-5'-DMT-2'-deoxyuridine |
| 2'-Deoxy-5'-O-DMT-5-iodouridine |
| 5'-DMT-5-I-2'-dU |
