Introduction：Basic information about CAS 485-65-4|Hydrocinchonine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Hydrocinchonine |
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| CAS Number | 485-65-4 | Molecular Weight | 296.40700 |
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| Density | 1.18 g/cm3 | Boiling Point | 467.1ºC at 760 mmHg |
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| Molecular Formula | C19H24N2O | Melting Point | 269 - 272ºC |
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| MSDS | ChineseUSA | Flash Point | 236.3ºC |
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| Symbol |
GHS07 | Signal Word | Warning |
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Names
| Name | hydrocinchonine |
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| Synonym | More Synonyms |
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Hydrocinchonine BiologicalActivity
| Description | Hydrocinchonine (Dihydrocinchonine) is a multidrug resistance (MDR)-reversal agent. Hydrocinchonine exerts synergistic apoptotic effect with Paclitaxel in MES-SA/DX5 cells[1]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Cancer |
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| References | [1]. Sang-Yun Lee, et al. Hydrocinchonine, cinchonine, and quinidine potentiate paclitaxel-induced cytotoxicity and apoptosis via multidrug resistance reversal in MES-SA/DX5 uterine sarcoma cells. Environ Toxicol. 2011 Aug;26(4):424-31. |
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Chemical & Physical Properties
| Density | 1.18 g/cm3 |
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| Boiling Point | 467.1ºC at 760 mmHg |
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| Melting Point | 269 - 272ºC |
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| Molecular Formula | C19H24N2O |
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| Molecular Weight | 296.40700 |
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| Flash Point | 236.3ºC |
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| Exact Mass | 296.18900 |
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| PSA | 36.36000 |
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| LogP | 3.32650 |
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| Vapour Pressure | 0mmHg at 25°C |
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| Index of Refraction | 1.639 |
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| InChIKey | WFJNHVWTKZUUTR-QAMTZSDWSA-N |
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| SMILES | CCC1CN2CCC1CC2C(O)c1ccnc2ccccc12 |
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Safety Information
| Symbol |
GHS07 |
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| Signal Word | Warning |
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| Hazard Statements | H302-H312-H332 |
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| Precautionary Statements | P280 |
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| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
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| Hazard Codes | Xn: Harmful; |
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| Risk Phrases | R20/21/22 |
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| Safety Phrases | 36/37 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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Synonyms
| MFCD00216716 |
| (1S)-((2R,4S,5R)-5-Ethylquinuclidin-2-yl)(quinolin-4-yl)methanol |
| EINECS 207-621-8 |
| 10,11-dihydro-cinchonan-9-ol |
| Cinconifine |
