Introduction：Basic information about CAS 2309-07-1|Methyl 4-hydroxy-3-methoxycinnamate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Methyl 4-hydroxy-3-methoxycinnamate |
|---|
| CAS Number | 2309-07-1 | Molecular Weight | 208.21 |
|---|
| Density | 1.2±0.1 g/cm3 | Boiling Point | 338.1±27.0 °C at 760 mmHg |
|---|
| Molecular Formula | C11H12O4 | Melting Point | 62-65°C |
|---|
| MSDS | / | Flash Point | 130.4±17.2 °C |
|---|
Names
| Name | trans-methylferulate |
|---|
| Synonym | More Synonyms |
|---|
Methyl 4-hydroxy-3-methoxycinnamate BiologicalActivity
| Description | Ferulic acid methyl ester (Methyl ferulate) is a derivative of ferulic acid, isolated from Stemona tuberosa, with anti-inflammatory and antioxidant properties[1][2]. Ferulic acid methyl ester is a cell membrane and brain permeable compound, shows free radical scavenging ability, used in the research of neurodegenerative disorders[1]. Ferulic acid methyl ester inhibits COX-2 expression, blocks p-p38 and p-JNK in primary bone marrow derived-macrophages[2]. |
|---|
| Related Catalog | Signaling Pathways >>MAPK/ERK Pathway >>p38 MAPKResearch Areas >>Inflammation/ImmunologyResearch Areas >>Neurological Disease |
|---|
| Target | p38 |
|---|
| In Vitro | Ferulic acid methyl ester (Methyl ferulate; 5, 10, 25 µg/mL) suppresses TNFα, IL6, IFNγ but not IL10, inhibits NO generation at 10 and 25 µg/mL, in primary bone marrow derived-macrophages (BMDMs)[2]. Ferulic acid methyl ester (25 µg/mL) inhibits COX-2 expression, blocks p-p38 and p-JNK[2]. |
|---|
| References | [1]. Sultana R. Ferulic acid ethyl ester as a potential therapy in neurodegenerative disorders. Biochim Biophys Acta. 2012 May;1822(5):748-52. [2]. Phuong NT, et al. Anti-inflammatory activity of methyl ferulate isolated from Stemona tuberosa Lour. Asian Pac J Trop Med. 2014 Sep;7S1:S327-31. |
|---|
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|
| Boiling Point | 338.1±27.0 °C at 760 mmHg |
|---|
| Melting Point | 62-65°C |
|---|
| Molecular Formula | C11H12O4 |
|---|
| Molecular Weight | 208.21 |
|---|
| Flash Point | 130.4±17.2 °C |
|---|
| Exact Mass | 208.073563 |
|---|
| PSA | 55.76000 |
|---|
| LogP | 1.40 |
|---|
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
|---|
| Index of Refraction | 1.575 |
|---|
| Storage condition | 2-8°C |
|---|
Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- GD9470000
- CHEMICAL NAME :
- Cinnamic acid, 4-hydroxy-3-methoxy-, methyl ester
- CAS REGISTRY NUMBER :
- 2309-07-1
- BEILSTEIN REFERENCE NO. :
- 2731141
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C11-H12-O4
- MOLECULAR WEIGHT :
- 208.23
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1189 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 25,187,1987
|
Safety Information
| Hazard Codes | Xi |
|---|
| Risk Phrases | R36/37/38 |
|---|
| Safety Phrases | S26-S36/37/39 |
|---|
| RTECS | GD9470000 |
|---|
| HS Code | 2918990090 |
|---|
Customs
| HS Code | 2918990090 |
|---|
| Summary | 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
|---|
Synonyms
| Ferulic acid methyl ester |
| Methyl (2E)-3-(4-hydroxy-3-methoxyphenyl)acrylate |
| ferulic acid amide |
| Ferulasaeure-amid |
| 2-Propenoic acid, 3- (4-hydroxy-3-methoxyphenyl)-, methyl ester |
| Ferulamid |
| Methyl ferulate |
| methyl (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate |
| 4-Hydroxy-3-methoxy-zimtsaeure-amid |
| Methyl 4-hydroxy-3-methoxycinnamate |
| 4-Oxy-3-methoxy-zimtsaeure-amid |
| Ferulamide |
| 4-hydroxy-3-methoxy-cinnamic acid amide |
| 4-Hydroxy-3-Methoxycinnamide |
| methyl (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate |
| MFCD00017208 |
| methyl 3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate |
| 2-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, methyl ester, (2E)- |
| 2-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, methyl ester (9CI) |
| CINNAMIC ACID,4-HYDROXY-3-METHOXY-,METHYL ESTER |
| CINNAMAMIDE,4-HYDROXY-3-METHOXY |
| methyl 3-(4-hydroxy-3-methoxyphenyl)acrylate |
| Ferulic amide |
| feruloylamide |
| 3-(4-Hydroxy-3-methoxyphenyl)-2-propenamide |
