CAS 1742-95-6|4-AMINO-1,8-NAPHTHALIMIDE

Introduction：Basic information about CAS 1742-95-6|4-AMINO-1,8-NAPHTHALIMIDE, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 4-AMINO-1,8-NAPHTHALIMIDE BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Articles32
7. Synonyms

Common Name	4-AMINO-1,8-NAPHTHALIMIDE
CAS Number	1742-95-6	Molecular Weight	212.20
Density	1.105 g/mL at 25ºC(lit.)	Boiling Point	544.1ºC at 760 mmHg
Molecular Formula	C₁₂H₈N₂O₂	Melting Point	360ºC
MSDS	ChineseUSA	Flash Point	282.8ºC
Symbol	GHS07	Signal Word	Warning

Names

Name	4-amino-1,8-naphthalimide
Synonym	More Synonyms

4-AMINO-1,8-NAPHTHALIMIDE BiologicalActivity

Description	4-Aminonaphthalimide is a potent PARP inhibitor and potentiates the cytotoxicity of γ-radiation in cancer cells[1].
Related Catalog	Research Areas >>CancerSignaling Pathways >>Epigenetics >>PARPSignaling Pathways >>Cell Cycle/DNA Damage >>PARP
References	[1]. Schlicker A, et al. 4-Amino-1,8-naphthalimide: a novel inhibitor of poly(ADP-ribose) polymerase and radiation sensitizer. Int J Radiat Biol. 1999 Jan;75(1):91-100.

Chemical & Physical Properties

Density	1.105 g/mL at 25ºC(lit.)
Boiling Point	544.1ºC at 760 mmHg
Melting Point	360ºC
Molecular Formula	C₁₂H₈N₂O₂
Molecular Weight	212.20
Flash Point	282.8ºC
Exact Mass	212.05900
PSA	75.95000
LogP	1.64270
Vapour Pressure	6.75E-12mmHg at 25°C
Index of Refraction	1.764
InChIKey	SSMIFVHARFVINF-UHFFFAOYSA-N
SMILES	Nc1ccc2c3c(cccc13)C(=O)NC2=O

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DE4081000

CHEMICAL NAME :: 1H-Benz(de)isoquinoline-1,3(2H)-dione, 6-amino-

CAS REGISTRY NUMBER :: 1742-95-6

BEILSTEIN REFERENCE NO. :: 0177185

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C12-H8-N2-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 42(1),111,1977

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	26-37/39
RIDADR	NONH for all modes of transport
RTECS	DE4081000

Articles32

A new polymerizable fluorescent PET chemosensor of fluoride (F-) based on naphthalimide-thiourea dye.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 90 , 85-92, (2012)

A novel N-allyl-4-amino-substituted 1,8-naphthalimide dye, containing thiourea functional group with intense yellow-green fluorescence was successfully synthesized. Copolymerization was done with styr...

Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responses.

DNA Repair (Amst.) 12(9) , 774-85, (2013)

Poly(ADP-ribose) polymerase-1 (PARP-1) binds intermediates of base excision repair (BER) and becomes activated for poly(ADP-ribose) (PAR) synthesis. PAR mediates recruitment and functions of the key B...

[Effect of PARP-1 inhibitor 4-amino-1 ,8-naphthalimide on the on the sensitivity of adriamycin].

Wei Sheng Yan Jiu 41(2) , 173-9, (2012)

To explore the effect of inhibition of poly (ADP-ribose) polymerase-1 (PARP-1) on the sensitivity of cells to adriamycin (ADM).Mouse embryonic fibroblasts (MEFs) were divided into two groups according...

Synonyms

6-aminobenzo[de]isoquinoline-1,3-dione

EINECS 217-092-5

4-Amino-1,8-naphthalimide

6-Amino-1H-benzo[de]isoquinoline-1,3(2H)-dione

MFCD00001892

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