Introduction：Basic information about CAS 7081-38-1|Oxyphenbutazone monohydrate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Oxyphenbutazone monohydrate |
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| CAS Number | 7081-38-1 | Molecular Weight | 342.38900 |
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| Density | / | Boiling Point | 485.6ºC at 760 mmHg |
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| Molecular Formula | C19H22N2O4 | Melting Point | 96°; mp 124-125° |
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| MSDS | / | Flash Point | 247.5ºC |
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Names
| Name | oxyphenbutazone hydrate |
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| Synonym | More Synonyms |
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Oxyphenbutazone monohydrate BiologicalActivity
| Description | Oxyphenbutazone monohydrate is a Phenylbutazone (HY-B0230) metabolite, with anti-inflammatory effect. Oxyphenbutazone monohydrate is an orally active non-selective COX inhibitor. Oxyphenbutazone monohydrate selectively kills non-replicating Mycobaterium tuberculosis[1][2]. |
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| Related Catalog | Research Areas >>InfectionResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Immunology/Inflammation >>COXSignaling Pathways >>Anti-infection >>Bacterial |
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| Target | COX, Bacteria[1][2] |
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| In Vitro | Oxyphenbutazone enhances the anticancer efficiency of Methotrexate (MTX) (HY-14519) in Hep3B cells[1]. Oxyphenbutazone (2.5-7.5 µM; 48 hours) co-treatment with (MTX, 0.25-1.0 µM) shows potential cytotoxicity against Hep3B cells[1]. Oxyphenbutazone exhibits reparative effects in the hepatocytes[1]. Cell Viability Assay[1] Cell Line: Hep3B cells Concentration: 2.5 µM, 5 µM, 7.5 µM Incubation Time: 48 hours Result: Enhanced the cytotoxicity of MTX. |
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| In Vivo | Oxyphenbutazone (70 mg/kg/week; p.o.; in two divided doses; for 13 weeks) exerts potential anticancer activity when co-treatment with MTX (5.0 or 2.5 mg/kg/week; i.p.)[1]. Animal Model: Wistar strain albino male rats (5-6 weeks; 150-220 g)[1] Dosage: 70 mg/kg/week (co-treatment with MTX 5.0 or 2.5 mg/kg/week) Administration: PO; once a week; in two divided doses; for 13 weeks Result: Exerted potential anticancer activity in rats when co-treatment with MTX. |
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| References | [1]. Saleem S, et al. Oxyphenbutazone promotes cytotoxicity in rats and Hep3B cellsvia suppression of PGE2 and deactivation of Wnt/β-catenin signaling pathway. Mol Cell Biochem. 2018 Jul;444(1-2):187-196. [2]. Gold B, et al. Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials. Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16004-11. |
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Chemical & Physical Properties
| Boiling Point | 485.6ºC at 760 mmHg |
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| Melting Point | 96°; mp 124-125° |
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| Molecular Formula | C19H22N2O4 |
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| Molecular Weight | 342.38900 |
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| Flash Point | 247.5ºC |
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| Exact Mass | 342.15800 |
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| PSA | 70.08000 |
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| LogP | 3.55910 |
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| InChIKey | CNDQSXOVEQXJOE-UHFFFAOYSA-N |
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| SMILES | CCCCC1C(=O)N(c2ccccc2)N(c2ccc(O)cc2)C1=O.O |
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| Storage condition | 2-8°C |
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Safety Information
| Hazard Codes | Xn |
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| Risk Phrases | 22-36/38-40-42/43 |
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| Safety Phrases | 22-26-36 |
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Synonyms
| oxyphenbutazon monohydrate |
| OXYPHENBUTAZONE HYDRATE |
| OXYPHENBUTAZONE MONOHYDRATE |
| OXYPHENYL BUTAZONE MONOHYDRATE |
| Unii-H806S4B3ns |
