CAS 103476-21-7|DL-3-Hydroxy-3-methylglutaryl coenzyme A disodium

Introduction：Basic information about CAS 103476-21-7|DL-3-Hydroxy-3-methylglutaryl coenzyme A disodium, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	DL-3-Hydroxy-3-methylglutaryl coenzyme A disodium
CAS Number	103476-21-7	Molecular Weight	955.623
Density	/	Boiling Point	/
Molecular Formula	C₂₇H₄₂N₇Na₂O₂₀P₃S	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	(DL-3-Hydroxy-3-methylglutaryl)-coenzyme A disodium salt trihydrate
Synonym	More Synonyms

BiologicalActivity

Description	DL-3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) disodium is a disodium salt compound of HMG-CoA, is a intermediate of terpenes and ketone bodies. DL-3-Hydroxy-3-methylglutaryl coenzyme A disodium also involves in ester metabolism in vivo, as a precursor for cholesterol synthesis, and regulates cholesterol synthesis by coupling LDL receptor[1][2].
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease
In Vitro	3-hydroxy-3-methylglutaryl CoA (HMG-CoA) comes from acetyl-coa and acetyl-CoA converted from HMG-CoA synthetase, mainly dependents on oxidative reactions in mitochondria[1].
References	[1]. Millán Núñez-Cortés J, et al. Fármacos hipolipemiantes y PCSK9 [Lipid-lowering drugs and PCSK9]. Clin Investig Arterioscler. 2016 May;28 Suppl 2:9-13. Spanish. [2]. Wang Wei, er al. The Key Enzyme of Cholesterol Synthesis Pathway:HMG CoA Reductase and Disease. PROGRESS IN PHYSIOLOGICAL SCIENCES. 1999. (01):7-11.

Chemical & Physical Properties

Molecular Formula	C₂₇H₄₂N₇Na₂O₂₀P₃S
Molecular Weight	955.623
Exact Mass	955.121338
PSA	481.55000
LogP	0.51990
InChIKey	XCMQYNRDGHLEPX-FZFZRPSRSA-L
SMILES	CC(O)(CC(=O)O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(n2cnc3c(N)ncnc32)C(O)C1OP(=O)([O-])[O-].[Na+].[Na+]
Storage condition	-20°C

Safety Information

WGK Germany	3.0

Synonyms

DL-3-Hydroxy-3-methylglutaryl coenzyme A sodium salt hydrate

Adenosine, 5'-O-[[[[(3R)-4-[[3-[[2-[(4-carboxy-3-hydroxy-3-methyl-1-oxobutyl)thio]ethyl]amino]-3-oxopropyl]amino]-3-hydroxy-2,2-dimethyl-4-oxobutoxy]hydroxyphosphinyl]oxy]hydroxyphosphinyl]-, 3'-(dihydrogen phosphate), sodium salt (1:2)

Disodium (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-2-[(9R)-22-carboxy-3,5,9,21-tetrahydroxy-8,8,21-trimethyl-3,5-dioxido-10,14,19-trioxo-2,4,6-trioxa-18-thia-11,15-diaza-3λ,5λ-diphosphad 
ocos-1-yl]-4-hydroxytetrahydro-3-furanyl phosphate

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