Introduction：Basic information about CAS 76420-72-9|Enalaprilat, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Enalaprilat |
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| CAS Number | 76420-72-9 | Molecular Weight | 348.39400 |
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| Density | 1.286 g/cm3 (20ºC) | Boiling Point | 601ºC at 760 mmHg |
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| Molecular Formula | C18H24N2O5 | Melting Point | 148-151°C |
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| MSDS | ChineseUSA | Flash Point | 317.3ºC |
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Names
| Name | enalaprilat (anhydrous) |
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| Synonym | More Synonyms |
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Enalaprilat BiologicalActivity
| Description | Enalaprilat (MK-422 anhydrous), the active metabolite of the oral prodrug Enalapril, is a potent, competitive and long-acting angiotensin-converting enzyme (ACE) inhibitor, with an IC50 of 1.94 nM. Enalaprilat can be used for the research of hypertension[1][2][3]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Metabolic Enzyme/Protease >>Angiotensin-converting Enzyme (ACE) |
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| Target | IC50: 1.94 nM (ACE)[1] |
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| In Vitro | Enalaprilat (1 nM-10 μM; 24 h) attenuates the IGF-I induced neonatal rat cardiac fibroblast growth (30% reduction) in a concentration-dependent fashion, with an IC50 of 90 mM[2]. |
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| In Vivo | Enalaprilat (0.01%-2.9% in the eyedrop solution) shows significant intraocular pressure (IOP)-lowering effect in rabbits[3]. |
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| References | [1]. Ceconi C, et, al. Angiotensin-converting enzyme (ACE) inhibitors have different selectivity for bradykinin binding sites of human somatic ACE. Eur J Pharmacol. 2007 Dec 22;577(1-3):1-6. [2]. Eickels M, et, al. Angiotensin-converting enzyme (ACE) inhibition attenuates insulin-like growth factor-I (IGF-I) induced cardiac fibroblast proliferation. Br J Pharmacol. 2000 Dec;131(8):1592-6. [3]. Loftsson T, et, al. Enalaprilat and enalapril maleate eyedrops lower intraocular pressure in rabbits. Acta Ophthalmol. 2010 May;88(3):337-41. |
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Chemical & Physical Properties
| Density | 1.286 g/cm3 (20ºC) |
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| Boiling Point | 601ºC at 760 mmHg |
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| Melting Point | 148-151°C |
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| Molecular Formula | C18H24N2O5 |
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| Molecular Weight | 348.39400 |
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| Flash Point | 317.3ºC |
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| Exact Mass | 348.16900 |
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| PSA | 106.94000 |
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| LogP | 1.45490 |
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| InChIKey | LZFZMUMEGBBDTC-QEJZJMRPSA-N |
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| SMILES | CC(NC(CCc1ccccc1)C(=O)O)C(=O)N1CCCC1C(=O)O |
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Safety Information
| Hazard Codes | Xn |
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| Risk Phrases | R68:Possible risk of irreversible effects. |
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| Safety Phrases | S22-S36/37/39 |
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| RTECS | DU9085000 |
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| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Vasotec IV |
| MFCD08060099 |
| ENALAPRILAT HYDRATE |
| L-Proline,1-[N-(1-carboxy-3-phenylpropyl)-L-alanyl]-,(S) |
| S-1-[N-(1-carboxy-3-phenylpropyl)-L-alanyl]-L-proline |
| ENALAPRILAT USP(CRM STANDARD) |
| Enalaprilat |
| Enalapril acid |
| Enalaprilic Acid |
| 1-[N-[(S)-1-Carboxy-3-phenylpropyl]-L-alanyl]-L-proline |
| N-(1(S)-carboxy-3-phenylpropyl)-L-alanyl-L-proline |
| enalaprilate |
| Enalapril diacid |
| EINECS 278-459-3 |
