CAS 106017-08-7|Rufloxacin (hydrochloride)

Introduction：Basic information about CAS 106017-08-7|Rufloxacin (hydrochloride), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Rufloxacin (hydrochloride) BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Synonyms

Common Name	Rufloxacin (hydrochloride)
CAS Number	106017-08-7	Molecular Weight	399.86700
Density	/	Boiling Point	574.6ºC at 760mmHg
Molecular Formula	C₁₇H₁₉ClFN₃O₃S	Melting Point	322-324ºC
MSDS	/	Flash Point	301.3ºC

Names

Name	rufloxacin hydrochloride
Synonym	More Synonyms

Rufloxacin (hydrochloride) BiologicalActivity

Description	Rufloxacin hydrochloride (MF-934 hydrochloride) is a fluoroquinolone antibacterial, inhibits B-cell differentiation in human mononuclear cells, inhibits Topo.
Related Catalog	Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>Infection

Chemical & Physical Properties

Boiling Point	574.6ºC at 760mmHg
Melting Point	322-324ºC
Molecular Formula	C₁₇H₁₉ClFN₃O₃S
Molecular Weight	399.86700
Flash Point	301.3ºC
Exact Mass	399.08200
PSA	91.08000
LogP	2.50120
InChIKey	LPQOADBMXVRBNX-UHFFFAOYSA-N
SMILES	CN1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn4c3c2SCC4)CC1.Cl
Storage condition	2-8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UU8174500

CHEMICAL NAME :: 7H-Pyrido(1,2,3-de)(1,4)benzothiazine-6-carboxylic acid, 2,3-dihydro-9-fluoro-10-(4-methyl-1- piperazinyl)-7-oxo-, monohydrochloride

CAS REGISTRY NUMBER :: 106017-08-7

LAST UPDATED :: 198709

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C17-H18-F-N3-O3-S.Cl-H

MOLECULAR WEIGHT :: 399.90

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 501 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 30,465,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 285 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 30,465,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 224 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 30,465,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 660 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 30,465,1987

Safety Information

HS Code	2942000000

Customs

HS Code	2942000000

Synonyms

7H-Pyrido[1,2,3-de]-1,4-benzothiazine-6-carboxylicacid,9-fluoro-2,3-dihydro-10-(4-methyl-1-piperazinyl)-7-oxo-,hydrochloride(1:1)

MF-934

MFCD00912283

9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acid hydrochloride

7H-Pyrido(1,2,3-de)(1,4)benzothiazine-6-carboxylic acid,2,3-dihydro-9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-,monohydrochloride

Rufloxacin (hydrochloride)

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