CAS 74-79-3|L-arginine

Introduction：Basic information about CAS 74-79-3|L-arginine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. L-arginine BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Safety Information
6. Customs
7. Articles396
8. Synonyms

Common Name	L-arginine
CAS Number	74-79-3	Molecular Weight	174.201
Density	1.5±0.1 g/cm3	Boiling Point	367.6±52.0 °C at 760 mmHg
Molecular Formula	C₆H₁₄N₄O₂	Melting Point	222 °C (dec.)(lit.)
MSDS	ChineseUSA	Flash Point	176.1±30.7 °C

Names

Name	L-arginine
Synonym	More Synonyms

L-arginine BiologicalActivity

Description	L-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.Target: OthersL-Arginine is an α-amino acid. It was first isolated in 1886. The L-form is one of the 20 most common natural amino acids. At the level of molecular genetics, in the structure of the messenger ribonucleic acid mRNA, CGU, CGC, CGA, CGG, AGA, and AGG, are the triplets of nucleotide bases or codons that code for arginine during protein synthesis. In mammals, arginine is classified as a semiessential or conditionally essential amino acid, depending on the developmental stage and health status of the individual.L-Arginine is associated with a decrease in cardiac index while stroke index is maintained in patients with severe sepsis. Resolution of shock at 72 hours is achieved by 40% and 24% of the patients in the L-Arginine and placebo cohorts, respectively. L-Arginine (450 mg/kg during a 15-minute period) amplifies and sustains the hyperemia (38%) and increases absolute brain blood flow after eNOS upregulation by chronic simvastatin treatment (2 mg/kg subcutaneously, daily for 14 days) in SV-129 mice.
Related Catalog	Signaling Pathways >>Immunology/Inflammation >>NO SynthaseNatural Products >>OthersResearch Areas >>Others
Target	Human Endogenous Metabolite
References	[1]. Tapiero H, et al. I. Arginine. Biomed Pharmacother. 2002 Nov;56(9):439-45. [2]. Bakker J, et al. Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002). Crit Care Med. 2004 Jan;32(1):1-12. [3]. Yamada M, et al. Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by L-arginine after chronic statin treatment. J Cereb Blood Flow Metab. 2000 Apr;20(4):709-17.

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Boiling Point	367.6±52.0 °C at 760 mmHg
Melting Point	222 °C (dec.)(lit.)
Molecular Formula	C₆H₁₄N₄O₂
Molecular Weight	174.201
Flash Point	176.1±30.7 °C
Exact Mass	174.111679
PSA	125.22000
LogP	-1.79
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.601
InChIKey	ODKSFYDXXFIFQN-BYPYZUCNSA-N
SMILES	NC(N)=NCCCC(N)C(=O)O
Water Solubility	148.7 g/L (20 ºC)

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CF1934200

CHEMICAL NAME :: Arginine, L-

CAS REGISTRY NUMBER :: 74-79-3

BEILSTEIN REFERENCE NO. :: 1725413

LAST UPDATED :: 199710

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C6-H14-N4-O2

MOLECULAR WEIGHT :: 174.24

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 10 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 372,75,1996 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 10 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3074 No. of Facilities: 685 (estimated) No. of Industries: 3 No. of Occupations: 14 No. of Employees: 19298 (estimated) No. of Female Employees: 15719 (estimated)

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn: Harmful;
Risk Phrases	R36
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	CF1934200
HS Code	2922499990

Customs

HS Code	2925290090
Summary	2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles396

Hepatitis E virus (HEV) protease: a chymotrypsin-like enzyme that processes both non-structural (pORF1) and capsid (pORF2) protein.

J. Gen. Virol. 95(Pt 8) , 1689-700, (2014)

Hepatitis E virus (HEV), a major cause of acute viral hepatitis across the world, is a non-enveloped, plus-strand RNA virus. Its genome codes three proteins, pORF1 (multifunctional polyprotein), pORF2...

Mechanistic studies on the flavin-dependent N⁶-lysine monooxygenase MbsG reveal an unusual control for catalysis.

Arch. Biochem. Biophys. 550-551 , 58-66, (2014)

The mechanism of Mycobacterium smegmatis G (MbsG), a flavin-dependent l-lysine monooxygenase, was investigated under steady-state and rapid reaction conditions using primary and solvent kinetic isotop...

Sustained Arginase 1 Expression Modulates Pathological Tau Deposits in a Mouse Model of Tauopathy.

J. Neurosci. 35 , 14842-60, (2015)

Tau accumulation remains one of the closest correlates of neuronal loss in Alzheimer's disease. In addition, tau associates with several other neurodegenerative diseases, collectively known as tauopat...

Synonyms

L-Arginine

L-ornithine, N-(diaminomethylene)-

MFCD00002635

H-L-ARG-OH

L-Argnie

(L)-Arginine

L-ARG-OH

L-arginie

AGRININE

arginine

L(+)-Arginine

L-Arginine (9CI)

QVYZ3MYZUM &&L or S Form

FEMA 3819

Pentanoic acid, 2-amino-5-[(aminoiminomethyl)amino]-, (S)-

EINECS 200-811-1

ARGININE, L-

L-a-Amino-d-guanidinovaleric Acid

L-Norvaline, 5-[(aminoiminomethyl)amino]-

(2S)-2-Amino-5-carbamimidamidopentanoic acid

H-ARG-OH

S-(+)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid

l-arginin

Arginine, L- (8CI)

Arginine (VAN)

l-arg

5-[(Aminoiminomethyl)amino]-L-norvaline

Arg

N5-(Aminoiminomethyl)-L-ornithine

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