Introduction：Basic information about CAS 72332-33-3|Procaterol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Procaterol |
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| CAS Number | 72332-33-3 | Molecular Weight | 290.36 |
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| Density | 1.191 g/cm3 | Boiling Point | 539.5ºC at 760 mmHg |
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| Molecular Formula | C16H22N2O3 | Melting Point | 170-173 °C(lit.) |
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| MSDS | / | Flash Point | / |
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Names
| Name | (R*,S*)-(-)-8-Hydroxy-5-(1-hydroxy-2-((1-methylethyl)amino)butyl)-2(1H)-quinolinone |
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| Synonym | More Synonyms |
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Procaterol BiologicalActivity
| Description | Procaterol is an oral selective β2 adrenergic receptor agonist. Procaterol inhibits eosinophil migration and the release of eosinophil chemotactic factor from BEAS-2B cells through a cyclic AMP-dependent mechanism. Procaterol has a large dose difference existing between the bronchodilator effect and the anabolic effect in rat, can be used for asthma research in athletes[1]. |
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| Related Catalog | Research Areas >>OthersSignaling Pathways >>GPCR/G Protein >>Adrenergic Receptor |
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| Target | β2 adrenoceptor |
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| References | [1]. Ikezono K, et al. Bronchodilating effect and anabolic effect of inhaled procaterol. Int J Sports Med. 2008 Nov;29(11):888-94. [2]. Tashimo H, et al. Effect of procaterol, a beta(2) selective adrenergic receptor agonist, on airway inflammation and hyperresponsiveness. Allergol Int. 2007 Sep;56(3):241-7. [3]. Koyama S, et al. Procaterol inhibits IL-1beta- and TNF-alpha-mediated epithelial cell eosinophil chemotactic activity. Eur Respir J. 1999 Oct;14(4):767-75. [4]. Yamaya M, et al. Procaterol inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells. Eur J Pharmacol. 2011 Jan 10;650(1):431-44. [5]. Komatani-Tamiya N, et al. Procaterol-stimulated increases in ciliary bend amplitude and ciliary beat frequency in mouse bronchioles. Cell Physiol Biochem. 2012;29(3-4):511-22. |
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Chemical & Physical Properties
| Density | 1.191 g/cm3 |
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| Boiling Point | 539.5ºC at 760 mmHg |
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| Melting Point | 170-173 °C(lit.) |
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| Molecular Formula | C16H22N2O3 |
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| Molecular Weight | 290.36 |
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| Exact Mass | 290.16300 |
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| PSA | 85.35000 |
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| LogP | 2.43460 |
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| InChIKey | FKNXQNWAXFXVNW-BLLLJJGKSA-N |
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| SMILES | CCC(NC(C)C)C(O)c1ccc(O)c2[nH]c(=O)ccc12 |
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| Storage condition | -20°C |
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| Water Solubility | 3000 g/L (20 ºC) |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- VC8295000
- CHEMICAL NAME :
- 2(1H)-Quinolinone, 8-hydroxy-5-(1-hydroxy-2-((1-methylethyl)amino)butyl) -, (R*,S*)-(+-)-
- CAS REGISTRY NUMBER :
- 72332-33-3
- LAST UPDATED :
- 198910
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C16-H22-N2-O3
- MOLECULAR WEIGHT :
- 290.40
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 320 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- SYXUE3 Shenyang Yaoxueyuan Xuebao. Journal of Shenyang College of Pharmacy. (Shenyang Yaoxueyuan, 7, 2-duan, Wenhualu, Shenhequ, Shenyang, Peop. Rep. China) V.1- 1984- Volume(issue)/page/year: 3,259,1986
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Safety Information
| Hazard Codes | Xn |
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| Risk Phrases | R22:Harmful if swallowed. R36/37/38:Irritating to eyes, respiratory system and skin . |
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| Safety Phrases | S26-S36/37-S37/39 |
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| WGK Germany | 1 |
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| RTECS | IQ0220000 |
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| HS Code | 29211190 |
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Customs
Synonyms
| 8-hydroxy-5-(1-hydroxy-2-((1-methylethyl)amino)butyl)-2(1h)-quinolinone(r*,s |
| EINECS 276-590-0 |
| s*)-(+-) |
| PROCATEROL |
| ent-Florfenicol AMine-d3 |
| (S)-N,N-DiMethyl-3-(1-naphthalenyl-d7-oxy)-3-(2-thienyl)propanaMine |
| MFCD01750015 |
