Introduction：Basic information about CAS 66778-36-7|BENZAMIDE, 4-METHOXY-N-[2-[2-(1-METHYL-2-PIPERIDINYL)ETHYL]PHENYL]-, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | BENZAMIDE, 4-METHOXY-N-[2-[2-(1-METHYL-2-PIPERIDINYL)ETHYL]PHENYL]- |
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| CAS Number | 66778-36-7 | Molecular Weight | 352.47000 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C22H28N2O2 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | encainide |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | Encainide (MJ9067) is an antiarrhythmic drug with class ⅠC activity. Encainide has the potential for life-threatening ventricular arrhythmias, symptomatic ventricular arrhythmias and supraventricular arrhythmias research[1]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Others >>Others |
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| In Vivo | Encainide (0.3, 0.9, 2.7 mg/kg; infusion of single doses) prolongs His-Purkinje conduction time (HV interval) and intra-ventricular conduction time (QRS duration) but has no effect on sinus nodal recovery time or AV nodal conduction, or on refractoriness of atrium, AV node, or ventricular myocardium or on QT interval[1]. |
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| References | [1]. R N Brogden, et al. Encainide. A review of its pharmacological properties and therapeutic efficacy. Drugs. 1987 Nov;34(5):519-38. |
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Chemical & Physical Properties
| Molecular Formula | C22H28N2O2 |
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| Molecular Weight | 352.47000 |
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| Exact Mass | 352.21500 |
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| PSA | 41.57000 |
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| LogP | 4.37530 |
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| InChIKey | PJWPNDMDCLXCOM-UHFFFAOYSA-N |
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| SMILES | COc1ccc(C(=O)Nc2ccccc2CCC2CCCCN2C)cc1 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- CV5521000
- CHEMICAL NAME :
- Benzamide, 4-methoxy-N-(2-(2-(1-methyl-2-piperidinyl)ethyl)pheny l)-, (+-)-
- CAS REGISTRY NUMBER :
- 66778-36-7
- BEILSTEIN REFERENCE NO. :
- 0497572
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C22-H28-N2-O2
- MOLECULAR WEIGHT :
- 352.52
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - infant
- DOSE/DURATION :
- 3289 ug/kg
- TOXIC EFFECTS :
- Cardiac - arrhythmias (including changes in conduction) Cardiac - change in rate
- REFERENCE :
- AEMED3 Annals of Emergency Medicine. (American College of Emergency Physicians, 1125 Executive Circle, Irving, TX 75038) Volume(issue)/page/year: 21,998,1992
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 43 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Cardiac - pulse rate increase, without fall in BP Vascular - BP lowering not characterized in autonomic section
- REFERENCE :
- AJCDAG American Journal of Cardiology. (Technical Pub. Co., 875 Third Ave., New York, NY 10022) V.1- 1958- Volume(issue)/page/year: 57,878,1986
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 3214 mg/kg/19H
- TOXIC EFFECTS :
- Cardiac - cardiomyopathy including infarction Cardiac - arrhythmias (including changes in conduction)
- REFERENCE :
- AHJOA2 American Heart Journal. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1925- Volume(issue)/page/year: 102,857,1981
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 2400 ug/kg/17H
- TOXIC EFFECTS :
- Cardiac - cardiomyopathy including infarction Cardiac - arrhythmias (including changes in conduction)
- REFERENCE :
- AHJOA2 American Heart Journal. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1925- Volume(issue)/page/year: 102,857,1981
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 1500 ug/kg
- TOXIC EFFECTS :
- Cardiac - arrhythmias (including changes in conduction)
- REFERENCE :
- AHJOA2 American Heart Journal. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1925- Volume(issue)/page/year: 102,857,1981
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 38100 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 281,277,1986
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Synonyms
| MJ-9067[AS BASE] |
| MJ-9067 |
| Enkaid |
| Encainida [spanish] |
| M-9067-1 |
| 4-methoxy-N-<2-<2-(1-methyl-2-piperidinyl)ethyl>phenyl>benzamide |
| Encainide [french] |
| Encainidum |
| Enkade |
| [14C]-Encainide |
| Encainida |
| (-)-Encainide |
| BENZAMIDE, 4-METHOXY-N-[2-[2-(1-METHYL-2-PIPERIDINYL)ETHYL]PHENYL]- |
| 4-methoxy-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide |
