CAS 303-26-4|UNII:T875VN0D6E
| Common Name | UNII:T875VN0D6E | ||
|---|---|---|---|
| CAS Number | 303-26-4 | Molecular Weight | 286.80 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 409.1±0.0 °C at 760 mmHg |
| Molecular Formula | C17H19ClN2 | Melting Point | 65-70 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 193.3±26.5 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 1-(4-Chlorobenzhydryl)piperazine |
|---|---|
| Synonym | More Synonyms |
UNII:T875VN0D6E BiologicalActivity
| Description | 1-(4-Chlorobenzhydryl)piperazine is a biochemical reagent that can be used as a biological material or organic compound for life science related research. |
|---|---|
| Related Catalog | Research Areas >>Others |
| In Vitro | 1-(4-氯苄基)哌嗪是美氯嗪和氯环嗪的无活性代谢物，在羟嗪和西替利嗪的商业制剂中也发现它是一种杂质。1-(4-氯苄基)哌嗪已被用于合成电压门控钠通道 1.7 (Nav1.7) 抑制剂、抗癌剂和抗组胺剂。 |
| References | [1]. Gaertner, HJ, Breyer, U., and Liomin, G.Chronic administration of chlorcyclizine and meclizine to rats: Accumulation of a metabolite formed by piperazine ring cleavage J. Pharmacol. Exp. Ther.185(2)195-201(1973) [2]. Kuntzman, R., Klutch, A., Tsai, I., et al.Physiological distribution and metabolic inactivation of chlorcyclizine and cyclizineJ. Pharmacol. Exp. Ther.149(1)29-35(1965) [3]. Simpson, D., Skellern, GG, and Miller, JHMethod for the control of known impurities in hydroxyzine hydrochlorideJ. Pharm . Biomed. Anal.14(8-10)1371-1375(1996) [4]. Javid, FS, Shafaat, A., and Zarghi, A. Determination of cetirizine and its impurities in bulk and tablet formulation using a validated capillary zone electrophoretic methodJ. Anal. Chem.69(5)442-447(2014) [5]. Back, SK, Kam, YL, Oh, JA, et al.Synthesis and evaluation of (4-chlorobenzhydryl) piperazine amides as sodium channel Nav7 inhibitorsBull. Korean Chem. Soc.36(9)2290-2297(2015) [6]. Yarim, M., Koksal, M., Durmaz, I., et al.Cancer cell cytotoxicities of 1-(4-substitutedbenzoyl)-4 -(4-chlorobenzhydryl)piperazine derivativesInt. J. Mol. Sci.13(7)8071-8085(2012) [7]. Narsaiah, AV, and Narssimha, P.Efficient synthesis of antihistamines clocinizine and chlorcyclizineMed. Chem. Res.21538- 541 (2012) |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 409.1±0.0 °C at 760 mmHg |
| Melting Point | 65-70 °C(lit.) |
| Molecular Formula | C17H19ClN2 |
| Molecular Weight | 286.80 |
| Flash Point | 193.3±26.5 °C |
| Exact Mass | 286.123688 |
| PSA | 15.27000 |
| LogP | 3.44 |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
| Index of Refraction | 1.592 |
| InChIKey | UZKBSZSTDQSMDR-UHFFFAOYSA-N |
| SMILES | Clc1ccc(C(c2ccccc2)N2CCNCC2)cc1 |
| Storage condition | Refrigerator |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 100 mg/kg
- SEX/DURATION :
- female 12-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 147,391,1965
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 500 mg/kg
- SEX/DURATION :
- female 12-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 147,391,1965
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
| Hazard Codes | Xi:Irritant |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S37/39-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | TL1772000 |
| HS Code | 2933599090 |
Customs
| HS Code | 2933599090 |
|---|---|
| Summary | 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Synonyms
| EINECS 206-137-4 |
| N-(4-CHLOROBENZHYDRYL)-PIPERAZINE |
| Hydroxyzine Related Compound A |
| 1-(α-Phenyl-4-chlorobenzyl)piperazine |
| Norchlorcyclizine |
| 1-(4-Chlorobenzhydry)piperazine |
| 1-((4-Chlorophenyl)(phenyl)methyl)piperazine |
| 1-[(4-Chlorophenyl)(phenyl)methyl]piperazine |
| 1-(4-Chlorobenzhydryl) piperazine |
| 1-(4-Chloro-α-phenylbenzyl)piperazine |
| 1-(p-chlorobenzhydryl)piperazine |
| N-[(4-chlorophenyl)phenylmethyl]piperazine |
| 1-(4-Chlorodiphenylmethyl)piperazine |
| 1-(4-chlorobenzhydryl)-piperazine |
| 1-(4-chlorobenzhydryl) |
| Piperazine, 1- (p-chloro-α-phenylbenzyl)- |
| Piperazine, 1-[(4-chlorophenyl)phenylmethyl]- |
| N-[1-(4-chlorophenyl)-1-(phenyl)methyl]piperazine |
| MFCD00005965 |
| Piperazine, 1-[α-(4-chlorophenyl)benzyl]- |
| UNII:T875VN0D6E |
| 4-(4-Chlorobenzhydryl)piperazine |
| (RS)-1-[(4-Chlorophenyl)phenylmethyl]piperazine |
| 1-[(4-chlorophenyl)phenylmethyl]-piperazine |
