CAS 72822-12-9|Dapiprazole

Introduction：Basic information about CAS 72822-12-9|Dapiprazole, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Dapiprazole BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Synonyms

Common Name	Dapiprazole
CAS Number	72822-12-9	Molecular Weight	325.451
Density	1.2±0.1 g/cm3	Boiling Point	538.9±60.0 °C at 760 mmHg
Molecular Formula	C₁₉H₂₇N₅	Melting Point	/
MSDS	/	Flash Point	279.7±32.9 °C

Names

Name	dapiprazole
Synonym	More Synonyms

Dapiprazole BiologicalActivity

Description	Dapiprazole is a potent, selective and orally active alpha-1 adrenoceptor antagonist. Dapiprazole suppresses the opioid withdrawal symptoms. Dapiprazole is also used as eye drops for reversing mydriasis[1][2][3].
Related Catalog	Research Areas >>EndocrinologySignaling Pathways >>GPCR/G Protein >>Adrenergic Receptor
Target	α1-adrenergic receptor
In Vivo	Dapiprazole hydrochloride (0-10 mg/kg or 0-3 mg/mice; i.p. or i.c.v.; once) reduces the overall severity of the opiate withdrawal symptoms in mice[1]. Animal Model: Swiss Albino male CD-1 mice weighing 20 -25 g, acute dependence model (mice were injected i.p. with morphine (25 mg/kg) and 2 h later with naloxone (12.5 mg/kg))[1] Dosage: 5, 7.5 and 10 mg/kg (i.p.) or 0.5, 1 and 3 mg/mice (i.c.v.), once Administration: Intraperitoneal injection or intracerebroventricular administration, once Result: Decreased jumping behavior, head shakes and paw shakes when administered just before naloxone. Resulted in a notable suppression of morphine withdrawal symptoms in a dose-related fashion when injected i.c.v..
References	[1]. Valeri P, et al. Effects of dapiprazole, clonidine and yohimbine on the development of dependence and withdrawal behaviour in mice. Drug Alcohol Depend. 1989 Jan;23(1):73-7. [2]. Allinson RW, et al. Reversal of mydriasis by dapiprazole. Ann Ophthalmol. 1990 Apr;22(4):131-3, 138. [3]. Hou RH, et al. Arousal and the pupil: why diazepam-induced sedation is not accompanied by miosis. Psychopharmacology (Berl). 2007 Nov;195(1):41-59.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	538.9±60.0 °C at 760 mmHg
Molecular Formula	C₁₉H₂₇N₅
Molecular Weight	325.451
Flash Point	279.7±32.9 °C
Exact Mass	325.226654
PSA	37.19000
LogP	2.44
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.658
InChIKey	RFWZESUMWJKKRN-UHFFFAOYSA-N
SMILES	Cc1ccccc1N1CCN(CCc2nnc3n2CCCC3)CC1

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XZ5625000

CHEMICAL NAME :: s-Triazolo(4,3-a)pyridine, 5,6,7,8-tetrahydro-3-(2-(4-(o-tolyl)-1-piperazinyl)et hyl)-, hydrochloride

CAS REGISTRY NUMBER :: 72822-12-9

LAST UPDATED :: 199009

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C19-H27-N5.Cl-H

MOLECULAR WEIGHT :: 361.97

WISWESSER LINE NOTATION :: T56 AN CNN&TJ B2- AT6N DNTJ DR B1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 260 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - miosis (pupillary constriction) Behavioral - changes in motor activity (specific assay) Behavioral - ataxia

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 32,668,1982

Synonyms

Rev-Eyes

1,2,4-Triazolo[4,3-a]pyridine, 5,6,7,8-tetrahydro-3-[2-[4-(2-methylphenyl)-1-piperazinyl]ethyl]-

3-[2-[4-(2-methylphenyl)piperazin-1-yl]ethyl]-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridine

5,6,7,8-Tetrahydro-3-[2-[4-(2-methylphenyl)-1-piperazinyl]ethyl]-1,2,4-triazolo[4,3-a]pyridine

Dapiprazole

Dapiprazol [German]

Dapirazol

Glamidolo

3-{2-[4-(2-Methylphenyl)piperazin-1-yl]ethyl}-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine

3-[2-(4-o-tolyl-piperazin-1-yl)-ethyl]-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridine

3-{2-[4-(2-Methylphenyl)-1-piperazinyl]ethyl}-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine

5,6,7,8-Tetrahydro-3-[2-(4-o-tolyl-1-piperazinyl)ethyl]-s-triazolo[4,3-a]pyridine

5,6,7,8-tetrahydro-3-[2-(4-o-tolyl-1-piperazin)ethyl]-1,2,4-triazolo[4,3-a]pyridine

Reversil

Dapiprazole [INN]

Dapiprazol

dapiprazolum

Dapirazolum

Recommended......