CAS 69756-53-2|Halofantrine

Introduction：Basic information about CAS 69756-53-2|Halofantrine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Halofantrine BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Halofantrine
CAS Number	69756-53-2	Molecular Weight	500.42400
Density	1.244 g/cm3	Boiling Point	596.2ºC at 760 mmHg
Molecular Formula	C₂₆H₃₀Cl₂F₃NO	Melting Point	136-138ºC
MSDS	/	Flash Point	314.4ºC

Names

Name	halofantrine
Synonym	More Synonyms

Halofantrine BiologicalActivity

Description	Halofantrine (SKF-102886 free base) is a highly lipophilic antimalarial active against Chloroquine-resistant strains of Plasmodium falciparum[1]. Halofantrine blocks HERG potassium channels[2].
Related Catalog	Research Areas >>InfectionSignaling Pathways >>Membrane Transporter/Ion Channel >>Potassium Channel
In Vitro	Halofantrine blocks HERG tail currents elicited on repolarization to 760 mV from +30 mV with an IC50 of 196.9 nM[2]. Halofantrine inhibits MDA-MB-231 triple-negative breast cancer (TNBC) cell proliferation with the IC50 of 7.73±0.23 μM[3]. Halofantrine exhibits activity against asexual forms (3D7A), asexual forms (3D7HT-GFP), and mature gametocytes IV-V with IC50s of 0.0011, 0.0012, and 6.70 μM, respectively[4]. Cell Viability Assay[3] Cell Line: MDA-MB-231 TNBC Concentration: 0, 2.50, 5.00, 10.00, 20.00, 40.00, and 80.00 μM Incubation Time: 3 days Result: IC50 was 7.73±0.23 μM.
References	[1]. A J Humberstone, et al. Effect of altered serum lipid concentrations on the IC50 of halofantrine against Plasmodium falciparum. J Pharm Sci. 1998 Feb;87(2):256-8. [2]. H Tie, et al. Inhibition of HERG potassium channels by the antimalarial agent halofantrine. Br J Pharmacol. 2000 Aug;130(8):1967-75. [3]. Ji-Hyun Lee, et al. CDA: combinatorial drug discovery using transcriptional response modules. PLoS One. 2012;7(8):e42573. [4]. Joël Lelièvre, et al. Activity of clinically relevant antimalarial drugs on Plasmodium falciparum mature gametocytes in an ATP bioluminescence "transmission blocking" assay. PLoS One. 2012;7(4):e35019.

Chemical & Physical Properties

Density	1.244 g/cm3
Boiling Point	596.2ºC at 760 mmHg
Melting Point	136-138ºC
Molecular Formula	C₂₆H₃₀Cl₂F₃NO
Molecular Weight	500.42400
Flash Point	314.4ºC
Exact Mass	499.16600
PSA	23.47000
LogP	8.64430
Index of Refraction	1.577
InChIKey	FOHHNHSLJDZUGQ-UHFFFAOYSA-N
SMILES	CCCCN(CCCC)CCC(O)c1cc2c(Cl)cc(Cl)cc2c2cc(C(F)(F)F)ccc12

Synonyms

3-DIBUTYLAMINO-1-(1,3-DICHLORO-6-TRIFLUOROMETHYL-PHENANTHREN-9-YL)-PROPAN-1-OL HCL

Halofan

1,3-dichloro-6-trifluoromethyl-9-[1-hydroxy-3-(dibutylamino)-propyl]-phenanthrene

3-(Dibutylamino)-1-(1,3-dichloro-6-(trifluoromethyl)phenanthren-9-yl)propan-1-ol

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