CAS 1076-38-6|4-Hydroxycoumarin
Introduction：Basic information about CAS 1076-38-6|4-Hydroxycoumarin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 4-Hydroxycoumarin | ||
|---|---|---|---|
| CAS Number | 1076-38-6 | Molecular Weight | 162.142 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 352.4±42.0 °C at 760 mmHg |
| Molecular Formula | C9H6O3 | Melting Point | 211-213 °C(lit.) |
| MSDS | USA | Flash Point | 165.4±20.7 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 4-hydroxycoumarin |
|---|---|
| Synonym | More Synonyms |
4-Hydroxycoumarin BiologicalActivity
| Description | 4-Hydroxycoumarin, a coumarin derivative, is one of the most versatile heterocyclic scaffolds and is frequently applied in the synthesis of various organic compounds. 4-Hydroxycoumarin possesses both electrophilic and nucleophilic properties. 4-Hydroxycoumarin derivatives are employed as the anticoagulant, antibacterial, antifungal, antiviral, antitumor, antiprotozoal, insecticidal, antimycobacterial, antimutagenic, antioxidant, anti-inflammatory agents, HIV protease inhibitors and tyrosine kinase inhibitors[1]. |
|---|---|
| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Others >>Others |
| References | [1]. Mohammadi Ziarani G, et al. The molecular diversity scope of 4-hydroxycoumarin in the synthesis of heterocyclic compounds via multicomponent reactions. Mol Divers. 2019 Jan 29. doi: 10.1007/s11030-019-09918-7. |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 352.4±42.0 °C at 760 mmHg |
| Melting Point | 211-213 °C(lit.) |
| Molecular Formula | C9H6O3 |
| Molecular Weight | 162.142 |
| Flash Point | 165.4±20.7 °C |
| Exact Mass | 162.031693 |
| PSA | 50.44000 |
| LogP | 1.60 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.660 |
| Water Solubility | PRACTICALLY INSOLUBLE |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- MPHEAE Medicina et Pharmacologia Experimentalis. (Basel, Switzerland) V.12-17, 1965-67. For publisher information, see PHMGBN. Volume(issue)/page/year: 17,497,1967
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 2,109,1946
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 750 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 128,126,1960
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi:Irritant |
| Risk Phrases | R22;R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | DJ3100000 |
| HS Code | 29322980 |
Customs
| HS Code | 2932209090 |
|---|---|
| Summary | 2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 4-Monohydroxycoumarin |
| 4-hydroxy-2H-benzopyran-2-one |
| 4-hydroxy-2-chromenone |
| 4-Hydroxy-2H-chromen-2-one |
| Benzotertonicacid |
| 4-Coumaryl alcohol |
| 4-Hydroxy Coumarin |
| 4-HYDROXYCUMARIN |
| 4-Coumarinol |
| 4-Hydroxy-2H-1-benzopyran-2-one |
| HydroxyCoumarin |
| COUMARIN KIT |
| 4-Hydroxycoumarine |
| 4-Hydroxycoumarin |
| benzotetronic acid |
| EINECS 214-060-2 |
| MFCD00006856 |
| 2H-1-Benzopyran-2-one, 4-hydroxy- |
| COUMARINOL |
| 4-hydroxy-coumari |
