Introduction：Basic information about CAS 1247-42-3|meprednisone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | meprednisone |
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| CAS Number | 1247-42-3 | Molecular Weight | 372.455 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 574.4±50.0 °C at 760 mmHg |
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| Molecular Formula | C22H28O5 | Melting Point | 204-206ºC |
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| MSDS | / | Flash Point | 315.2±26.6 °C |
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Names
| Name | Meprednisone |
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| Synonym | More Synonyms |
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meprednisone BiologicalActivity
| Description | Meprednisone is a glucocorticoid and a methylated derivative of prednisone.Target: Glucocorticoid ReceptorMeprednisone is a glucocorticoid and a methylated derivative of prednisone. The methylprednisone to MPL area under the curve ratio decreased from 0.19 +/- 0.04 in control to 0.14 +/- 0.03 in ketoconazole-treated rats (P less than .05) due to altered interconversion between these steroids. An improved pharmacokinetic/dynamic receptor/gene-mediated model characterized the steroid receptor binding and induction of tyrosine aminotransferase activity after i.v. MPL sodium succinate (10 mg/kg). In contrast to previous in vitro studies, ketoconazole at maximally tolerated doses failed to antagonize the steroid receptor-mediated activity of MPL [1]. |
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| Related Catalog | Signaling Pathways >>Autophagy >>AutophagySignaling Pathways >>GPCR/G Protein >>Glucocorticoid ReceptorResearch Areas >>Metabolic Disease |
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| References | [1]. Scheuer, E. and E. Warshaw, Allergy to corticosteroids: update and review of epidemiology, clinical characteristics, and structural cross-reactivity. Am J Contact Dermat, 2003. 14(4): p. 179-87. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 574.4±50.0 °C at 760 mmHg |
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| Melting Point | 204-206ºC |
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| Molecular Formula | C22H28O5 |
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| Molecular Weight | 372.455 |
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| Flash Point | 315.2±26.6 °C |
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| Exact Mass | 372.193665 |
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| PSA | 91.67000 |
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| LogP | 2.06 |
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| Vapour Pressure | 0.0±3.6 mmHg at 25°C |
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| Index of Refraction | 1.595 |
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| InChIKey | PIDANAQULIKBQS-RNUIGHNZSA-N |
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| SMILES | CC1CC2C3CCC4=CC(=O)C=CC4(C)C3C(=O)CC2(C)C1(O)C(=O)CO |
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| Storage condition | 2~8°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- TU4154090
- CHEMICAL NAME :
- Pregna-1,4-diene-3,11,20-trione, 17,21-dihydroxy-16-beta-methyl-
- CAS REGISTRY NUMBER :
- 1247-42-3
- LAST UPDATED :
- 198910
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C22-H28-O5
- MOLECULAR WEIGHT :
- 372.50
- WISWESSER LINE NOTATION :
- L E5 B666 CV OV AHTTT&J A1 E1 FV1Q FQ G1
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 14 mg/kg
- SEX/DURATION :
- female 16-22 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - blood and lymphatic systems (including spleen and marrow) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
- REFERENCE :
- EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 30,1098,1974
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 6250 ug/kg
- SEX/DURATION :
- female 15-19 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Effects on Newborn - biochemical and metabolic
- REFERENCE :
- PEREBL Pediatric Research. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1967- Volume(issue)/page/year: 11,1042,1977
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Safety Information
| RIDADR | NONH for all modes of transport |
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| HS Code | 2937210000 |
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Customs
Synonyms
| (16b)-17,21-Dihydroxy-16-methylpregna-1,4-diene-3,11,20-trione |
| 16β-Methylprednisone |
| methylprednisone |
| deltisonab |
| (16β)-17,21-Dihydroxy-16-methylpregna-1,4-diene-3,11,20-trione |
| Deltisona B |
| 16b-Methylprednisone |
| Betapred |
| Betalone |
| Betapar |
| Pregna-1,4-diene-3,11,20-trione, 17,21-dihydroxy-16-methyl-, (16β)- |
| 17,21-Dihydroxy-16β-methylpregna-1,4-diene-3,11,20-trione |
| meprednisone |
| 17,21-Dihydroxy-16b-methylpregna-1,4-diene-3,11,20-trione |
| Bitanisone |
| Betanisona |
