CAS 103131-69-7|Kinetensin

Introduction：Basic information about CAS 103131-69-7|Kinetensin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Kinetensin BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Kinetensin
CAS Number	103131-69-7	Molecular Weight	1172.38000
Density	1.41 g/cm3	Boiling Point	/
Molecular Formula	C₅₆H₈₅N₁₇O₁₁	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	Kinetensin (human)
Synonym	More Synonyms

Kinetensin BiologicalActivity

Description	Kinetensin is a neurotensin-like peptide isolated from pepsin-treated human plasma.
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Neurotensin ReceptorPeptidesResearch Areas >>Neurological Disease
Target	Neurotensin Receptor[1]
In Vitro	The peptide kinetensin isolated from pepsin-treated human plasma induces a dose-dependent release of histamine when exposed to rat peritoneal mast cells. The threshold concentration is around 1 μM, the ED50 is 10 μM, and the optimal concentration of between 100 to 1000 μM released 80% of the total histamine. Kinetensin is 10 to 100 times less potent than neurotensin and equipotent with the opioid peptide dynorphin. The histamine release is clearly temperature-dependent, with no release occurring at 0 or 45 °C and with an optimum around 37 °C. The histamine release is significantly reduced in the absence of extracellular calcium[2].
In Vivo	Kinetensin also induces a dose-dependent increase in vascular permeability when injected intradermally into rats[2].
Cell Assay	Rat peritoneal mast cells are incubated with kinetensin at 37°C for 10 min. The incubation is stopped by the addition of 1.8 mL of ice-cold buffered saline and cells are separated from supernatant by centrifugation. Histamine release is expressed as per cent of total mast cell histamine[2].
Animal Admin	Rats[2] Anesthetized Sprague-Dawley rats are given 25I-albumin i.v. Samples are then injected intradermally in 5x2 spots on the back and comprised saline as a control or kinetensin in different doses in 100 μL saline. After 20 rain, skin biopsies of 7 mm diameter are cut out, weighed and transferred to a gamma-counter. Results are expressed as: (counts per min (cpm) in tissue per gram wet weight/cpm in plasma per mL plasma)[2].
References	[1]. Mogard MH, et al. The amino acid sequence of kinetensin, a novel peptide isolated from pepsin-treated human plasma: homology with human serum albumin, neurotensin and angiotensin. Biochem Biophys Res Commun. 1986 May 14;136(3):983-8. [2]. Sydbom A, et al. Stimulation of histamine release by the peptide kinetensin. Agents Actions. 1989 Apr;27(1-2):68-71.

Chemical & Physical Properties

Density	1.41 g/cm3
Molecular Formula	C₅₆H₈₅N₁₇O₁₁
Molecular Weight	1172.38000
Exact Mass	1171.66000
PSA	460.04000
LogP	4.33470
Index of Refraction	1.661
InChIKey	PANUJGMSOSQAAY-IHXGQVBNSA-N
SMILES	CCC(C)C(N)C(=O)NC(C)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(Cc1cnc[nH]1)C(=O)N1CCCC1C(=O)NC(Cc1ccc(O)cc1)C(=O)NC(Cc1ccccc1)C(=O)NC(CC(C)C)C(=O)O
Storage condition	2~8°C

Safety Information

Hazard Codes	F+
Safety Phrases	22-24/25
WGK Germany	3.0

Synonyms

nrp

h-ile-ala-arg-arg-his-pro-tyr-phe-leu-oh

ile-ala-arg-arg-his-pro-tyr-phe-leu

iarrhpyfl

kinetensin

neurotensin-related peptide

Recommended......