Introduction：Basic information about CAS 121932-06-7|PKA Inhibitor Fragment (6-22) amide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | PKA Inhibitor Fragment (6-22) amide |
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| CAS Number | 121932-06-7 | Molecular Weight | 1868.06000 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C80H130N28O24 | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | / |
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Names
| Name | Protein Kinase A Inhibitor Fragment 6-22 amide |
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| Synonym | More Synonyms |
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PKA Inhibitor Fragment (6-22) amide BiologicalActivity
| Description | PKA Inhibitor Fragment (6-22) amide is an inhibitor of cAMP-dependent protein kinase A (PKA), with a Ki of 2.8 nM. PKA Inhibitor Fragment (6-22) amide can significantly reverse low-level morphine antinociceptive tolerance in mice[1][2]. |
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| Related Catalog | Signaling Pathways >>Protein Tyrosine Kinase/RTK >>PKASignaling Pathways >>Stem Cell/Wnt >>PKAResearch Areas >>Neurological Disease |
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| Target | PKA:2.8 nM (Ki) |
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| References | [1]. Katz BM, et, al. Synthesis, characterization and inhibitory activities of (4-N3[3,5-3H]Phe10)PKI(6-22)amide and its precursors: photoaffinity labeling peptides for the active site of cyclic AMP-dependent protein kinase. Int J Pept Protein Res. 1989 Jun;33(6):439 [2]. Dalton GD, et, al. Alterations in brain Protein Kinase A activity and reversal of morphine tolerance by two fragments of native Protein Kinase A inhibitor peptide (PKI). Neuropharmacology. 2005 Apr; 48(5): 648-57. |
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Chemical & Physical Properties
| Molecular Formula | C80H130N28O24 |
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| Molecular Weight | 1868.06000 |
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| Exact Mass | 1866.98000 |
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| PSA | 881.72000 |
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| InChIKey | VAKHFAFLRUNHLQ-PEBJKXEYSA-N |
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| SMILES | CCC(C)C(NC(=O)C(C)NC(=O)C(CC(N)=O)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)CNC(=O)C(NC(=O)C(CCCNC(=N)N)NC(=O)CNC(=O)C(CO)NC(=O)C(C)NC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(CC(=O)O)NC(=O)C(C)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(N)C(C)O)C(C)CC)C(C)O)C(N)=O |
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| Storage condition | −20°C |
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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Articles1
More Articles
| Protein kinase inhibitor-(6-22)-amide peptide analogs with standard and nonstandard amino acid substitutions for phenylalanine 10. Inhibition of cAMP-dependent protein kinase. J. Biol. Chem. 264 , 14579, (1989) The minimal structure in the heat-stable inhibitor protein of cAMP-dependent protein kinase required for a low nanomolar potency of inhibition is the peptide Thr6-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-T... | |
Synonyms
| Protein Kinase A Inhibitor Fragment 6-22 amide |
| PKA inhibitor fragment (6-22) amide |
| MFCD00133792 |
