CAS 136553-81-6|BQ-123

Introduction：Basic information about CAS 136553-81-6|BQ-123, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. BQ-123 BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles41
6. Synonyms

Common Name	BQ-123
CAS Number	136553-81-6	Molecular Weight	610.701
Density	1.3±0.1 g/cm3	Boiling Point	1053.6±65.0 °C at 760 mmHg
Molecular Formula	C₃₁H₄₂N₆O₇	Melting Point	/
MSDS	ChineseUSA	Flash Point	591.0±34.3 °C

Names

Name	bq-123
Synonym	More Synonyms

BQ-123 BiologicalActivity

Description	BQ-123 is an ETA endothelin receptor antagonist (Ki values are 1.4 and 1500 nM at ETA and ETB receptors respectively) . 1) Reduces ischemia-induced ventricular arrhythmias in a rat model.2) BQ-123 prevents LPS-induced preterm birth in mice via the induction of uterine and placental IL-10.3) The reference for animal injections is 6.7 mg/kg. 4) BQ-123 decreased IL-1β and TNFα in the placenta while also decreasing transcription of ET-1 in the uterus.
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Endothelin ReceptorResearch Areas >>Infection
References	[1]. Olgun NS et al. BQ-123 prevents LPS-induced preterm birth in mice via the induction of uterine and placental IL-10. Toxicol Appl Pharmacol, 2015 Feb 1;282(3):275-84. [2]. Kanashiro A et al. Cytokines, but not corticotropin-releasing factor and endothelin-1, participate centrally in the febrile response in zymosan-induced arthritis in rats. Brain Res, 2015 Jun 12, 1610:12-9. [3]. Erdogan H et al. The protective effects of endothelin-A receptor antagonist BQ-123 in pentylenetetrazole-induced seizure in rats. Hum Exp Toxicol, 2014 Oct, 33(10):1008-16.

Description

BQ-123 is an ETA endothelin receptor antagonist (Ki values are 1.4 and 1500 nM at ETA and ETB receptors respectively) . 1) Reduces ischemia-induced ventricular arrhythmias in a rat model.2) BQ-123 prevents LPS-induced preterm birth in mice via the induction of uterine and placental IL-10.3) The reference for animal injections is 6.7 mg/kg. 4) BQ-123 decreased IL-1β and TNFα in the placenta while also decreasing transcription of ET-1 in the uterus.

Related Catalog

Signaling Pathways >>GPCR/G Protein >>Endothelin ReceptorResearch Areas >>Infection

References

[1]. Olgun NS et al. BQ-123 prevents LPS-induced preterm birth in mice via the induction of uterine and placental IL-10. Toxicol Appl Pharmacol, 2015 Feb 1;282(3):275-84.

[2]. Kanashiro A et al. Cytokines, but not corticotropin-releasing factor and endothelin-1, participate centrally in the febrile response in zymosan-induced arthritis in rats. Brain Res, 2015 Jun 12, 1610:12-9.

[3]. Erdogan H et al. The protective effects of endothelin-A receptor antagonist BQ-123 in pentylenetetrazole-induced seizure in rats. Hum Exp Toxicol, 2014 Oct, 33(10):1008-16.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	1053.6±65.0 °C at 760 mmHg
Molecular Formula	C₃₁H₄₂N₆O₇
Molecular Weight	610.701
Flash Point	591.0±34.3 °C
Exact Mass	610.311523
PSA	189.80000
LogP	-0.10
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.621
InChIKey	VYCMAAOURFJIHD-PJNXIOHISA-N
SMILES	CC(C)CC1NC(=O)C(C(C)C)NC(=O)C2CCCN2C(=O)C(CC(=O)O)NC(=O)C(Cc2c[nH]c3ccccc23)NC1=O
Storage condition	-20℃

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport

Articles41

A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis.

Sci. Signal. 8 , ra71, (2015)

Loss of NOTCH signaling in postnatal murine joints results in osteoarthritis, indicating a requirement for NOTCH during maintenance of joint cartilage. However, NOTCH signaling components are substant...

Subnormothermic ex vivo liver perfusion reduces endothelial cell and bile duct injury after donation after cardiac death pig liver transplantation.

Liver Transpl. 20(11) , 1296-305, (2014)

An ischemic-type biliary stricture (ITBS) is a common feature after liver transplantation using donation after cardiac death (DCD) grafts. We compared sequential subnormothermic ex vivo liver perfusio...

Gene expression profiling and endothelin in acute experimental pancreatitis.

World J. Gastroenterol. 18(32) , 4257-69, (2012)

To analyze gene expression profiles in an experimental pancreatitis and provide functional reversal of hypersensitivity with candidate gene endothelin-1 antagonists.Dibutyltin dichloride (DBTC) is a c...

Synonyms

Cyclo(L-α-aspartyl-L-prolyl-D-valyl-L-leucyl-D-tryptophyl)

d-trp-d-asp-pro-d-val-leu

bq-518

MFCD00133204

BQ-123

m.w. 610.70 c31h42n6o7

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