CAS 6971-97-7|Benzaldehyde,3-chloro-, 2-[(3-chlorophenyl)methylene]hydrazone
| Common Name | Benzaldehyde,3-chloro-, 2-[(3-chlorophenyl)methylene]hydrazone | ||
|---|---|---|---|
| CAS Number | 6971-97-7 | Molecular Weight | 277.14900 |
| Density | 1.21g/cm3 | Boiling Point | 387.794ºC at 760 mmHg |
| Molecular Formula | C14H10Cl2N2 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 188.331ºC |
| Symbol | GHS05, GHS07, GHS09 | Signal Word | Danger |
Names
| Name | DCB,[(3-Chlorophenyl)methylene]hydrazone-3-chlorobenzaldehyde |
|---|---|
| Synonym | More Synonyms |
BiologicalActivity
| Description | DCB (3,3′-dichlorobenzaldazine) is an neutral allosteric modulator of themetabotropic glutamate receptor metabotropic glutamate receptor subtype 5 (mGluR5) . DCB blocks the positive allosteric regulation of mGluRs (mGluR5) with the help of 3,3′-difluorobenzaldazine (DFB). DCB shows the negative modulatory effect of 3,3′-dimethoxybenzaldazine (DMeOB)[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>mGluRResearch Areas >>Neurological Disease |
| Target | mGluR 5 |
| References | [1]. O'Brien JA, et al. A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5. Mol Pharmacol. 2003; 64(3):731-40. |
Chemical & Physical Properties
| Density | 1.21g/cm3 |
|---|---|
| Boiling Point | 387.794ºC at 760 mmHg |
| Molecular Formula | C14H10Cl2N2 |
| Molecular Weight | 277.14900 |
| Flash Point | 188.331ºC |
| Exact Mass | 276.02200 |
| PSA | 24.72000 |
| LogP | 4.44640 |
| Index of Refraction | 1.59 |
| InChIKey | XMOVWXSCYLINBJ-UHFFFAOYSA-N |
| SMILES | Clc1cccc(C=NN=Cc2cccc(Cl)c2)c1 |
Safety Information
| Symbol | GHS05, GHS07, GHS09 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H302-H315-H317-H318-H335-H410 |
| Precautionary Statements | P261-P273-P280-P305 + P351 + P338-P501 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn,N |
| Risk Phrases | 22-37/38-41-43-50/53 |
| Safety Phrases | 26-36/37-60-61 |
| RIDADR | UN 3077 9/PG 3 |
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Synonyms
| Benzaldehyde,m-chloro-,azine |
| 3,3'-Dichlor-benzaldorzin |
| 3.3'-Dichlor-benzaldazin |
| 3,3'-DICHLOROBENZALDAZINE |
| 3,3'-Dichlorobenzylideneazine |
