CAS 119911-68-1|Calcitonin Gene Related Peptide Fragment 8-37 human
| Common Name | Calcitonin Gene Related Peptide Fragment 8-37 human | ||
|---|---|---|---|
| CAS Number | 119911-68-1 | Molecular Weight | 3125.59000 |
| Density | 1.46±0.1 g/cm3 | Boiling Point | / |
| Molecular Formula | C139H230N44O38 | Melting Point | / |
| MSDS | USA | Flash Point | / |
Names
| Name | CGRP 8-37 (human) |
|---|---|
| Synonym | More Synonyms |
BiologicalActivity
| Description | HCGRP-(8-37) is a human calcitonin gene-related peptide (hCGRP) fragment and also an antagonist of CGRP receptor. Sequence: Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>CGRP ReceptorSignaling Pathways >>Neuronal Signaling >>CGRP ReceptorPeptidesResearch Areas >>Cardiovascular DiseaseResearch Areas >>Metabolic Disease |
| Target | CGRP receptor[1] |
| References | [1]. Chiba T, et al. Calcitonin gene-related peptide receptor antagonist human CGRP-(8-37). Am J Physiol. 1989 Feb;256(2 Pt 1):E331-5. |
Chemical & Physical Properties
| Density | 1.46±0.1 g/cm3 |
|---|---|
| Molecular Formula | C139H230N44O38 |
| Molecular Weight | 3125.59000 |
| Exact Mass | 3123.74000 |
| PSA | 1339.16000 |
| LogP | 1.11560 |
| Appearance of Characters | powder |
| InChIKey | NDACAFBDTQIYCQ-YVQXRMNASA-N |
| SMILES | CC(C)CC(NC(=O)CNC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(NC(=O)C(N)C(C)C)C(C)O)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCCNC(=N)N)C(=O)NC(CO)C(=O)NCC(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(CC(N)=O)C(=O)NC(CC(N)=O)C(=O)NC(Cc1ccccc1)C(=O)NC(C(=O)N1CCCC1C(=O)NC(C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NCC(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)NC(Cc1ccccc1)C(N)=O)C(C)C)C(C)O)C(C)C)C(C)C)C(C)C |
| Storage condition | −20°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles31
More Articles| Calcitonin gene-related peptide stimulates proliferation and osteogenic differentiation of osteoporotic rat-derived bone mesenchymal stem cells. Mol. Cell Biochem. 402(1-2) , 101-10, (2015) Osteoporosis, a systemic bone disorder, is prevalent in postmenopausal woman. Bone mesenchymal stem cells (BMSCs), precursors of osteogenic cells, may contribute to prevention or treatment of bone fru... | |
| Intermedin enhances sympathetic outflow via receptor-mediated cAMP/PKA signaling pathway in nucleus tractus solitarii of rats. Peptides 47 , 1-6, (2013) Direct administration of intermedin (IMD) into the brain elicits cardiovascular effects different from the systemic administration. Nucleus tractus solitarii (NTS) is an important region for the cardi... | |
| Intermedin in paraventricular nucleus attenuates sympathetic activity and blood pressure via nitric oxide in hypertensive rats. Hypertension 63(2) , 330-7, (2014) Intermedin (IMD) is a member of calcitonin/calcitonin gene-related peptide family, which shares the receptor system consisting of calcitonin receptor-like receptor (CRLR) and receptor activity-modifyi... |
Synonyms
| FBHuman |
| CGRP-I 8-37 |
| EINECS 232-693-2 |
| CGRP-I 8-37,HUMAN |
| MFCD00133153 |
| VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASN-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-LYS-ALA-PHE-NH2 |
| ALA-CYS-ASN-THR-ALA-THR-CYS-VAL-THR-HIS-ARG-LEU-ALA-ASP-PHE-LEU-SER-ARG-SER-GLY-GLY-VAL-GLY-LYS-ASN-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-LYS-ALA-PHE-NH2: ACNTATCVTHRLADFLSRSGGVGKNNFVPTNVGSKAF-NH2DISULFIDE BRIDGE |
| CYS2-CYS7 |
| HCGRP-(8-37) |
