CAS 57444-62-9|Resiniferatoxin
| Common Name | Resiniferatoxin | ||
|---|---|---|---|
| CAS Number | 57444-62-9 | Molecular Weight | 628.71 |
| Density | 1.35g/cm3 | Boiling Point | 768.7ºC at 760mmHg |
| Molecular Formula | C37H40O9 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 240.3ºC |
| Symbol | GHS05, GHS06 | Signal Word | Danger |
Names
| Name | resiniferatoxin |
|---|---|
| Synonym | More Synonyms |
Resiniferatoxin BiologicalActivity
| Description | Resiniferatoxin ((+)-Resiniferatoxin), is a selective agonist of transient receptor potential vanilloid 1 (TRPV1) receptor agonist. Resiniferatoxin can be isolated from the Euphorbia resinifera plant. Resiniferatoxin eliminates TRPV1+ primary sensory afferents and blunt cardiac sympathetic afferent reflex for a relatively long period[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>TRP ChannelResearch Areas >>Cardiovascular Disease |
| In Vitro | Resiniferatoxin 导致通道开放时间延长和钙内流，从而导致对 TRPV1 阳性疼痛纤维或细胞体的细胞毒性[1]。 |
| In Vivo | Resiniferatoxin (2 μg/10 μl；鞘内注射到 T2/T3 间隙；冠状动脉闭塞后 4 周诱导大鼠心力衰竭) 显著和选择性地消除背角的传入标记物表达 (TRPV1 和降钙素基因相关肽) 并减少过度激活的 CSNA。Resiniferatoxin 显著逆转动作电位持续时间 (APD) 和 APD 交替的延长，降低室性心律失常的诱发性[2]。 |
| References | [1]. Brown DC. Resiniferatoxin: The Evolution of the "Molecular Scalpel" for Chronic Pain Relief. Pharmaceuticals (Basel). 2016;9(3):47. Published 2016 Aug 11. [2]. Wu Y, et al. Resiniferatoxin reduces ventricular arrhythmias in heart failure via selectively blunting cardiac sympathetic afferent projection into spinal cord in rats. Eur J Pharmacol. 2020;867:172836. |
Chemical & Physical Properties
| Density | 1.35g/cm3 |
|---|---|
| Boiling Point | 768.7ºC at 760mmHg |
| Molecular Formula | C37H40O9 |
| Molecular Weight | 628.71 |
| Flash Point | 240.3ºC |
| Exact Mass | 628.26700 |
| PSA | 120.75000 |
| LogP | 4.74470 |
| Index of Refraction | 1.643 |
| InChIKey | DSDNAKHZNJAGHN-WLJYXNHNSA-N |
| SMILES | C=C(C)C12CC(C)C34OC(Cc5ccccc5)(OC1C3C=C(COC(=O)Cc1ccc(O)c(OC)c1)CC1(O)C(=O)C(C)=CC14)O2 |
| Storage condition | 20°C |
Safety Information
| Symbol | GHS05, GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H314 |
| Precautionary Statements | P280-P305 + P351 + P338-P310 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | T |
| Risk Phrases | 25-35 |
| Safety Phrases | S26;S45;S36/S37/S39 |
| RIDADR | UN 2928 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | CY1633700 |
| Packaging Group | II |
| Hazard Class | 6.1(a) |
Articles43
More Articles| Activation of the TRPV1 cation channel contributes to stress-induced astrocyte migration. Glia 62(9) , 1435-51, (2014) Astrocytes provide metabolic, structural, and synaptic support to neurons in normal physiology and also contribute widely to pathogenic processes in response to stress or injury. Reactive astrocytes c... | |
| TRPM5-dependent amiloride- and benzamil-insensitive NaCl chorda tympani taste nerve response. Am. J. Physiol. Gastrointest. Liver Physiol. 305(1) , G106-17, (2013) Transient receptor potential (TRP) subfamily M member 5 (TRPM5) cation channel is involved in sensing sweet, bitter, umami, and fat taste stimuli, complex-tasting divalent salts, and temperature-induc... | |
| Inhibition by capsaicin and its related vanilloids of compound action potentials in frog sciatic nerves. Life Sci. 92(6-7) , 368-78, (2013) Although capsaicin not only activates transient receptor potential vanilloid-1 (TRPV1) channels but also inhibits nerve conduction, the latter action has not yet been fully examined. The purpose of th... |
Synonyms
| MFCD00135927 |
| Resiniferatoxin,4-Hydroxy-3-methoxy-[(2S,3aR,3bS,6aR,9aR,9bR,10R,11aR)-3a,3b,6,6a,9a,10,11,11a-octahydro-6a-hydroxy-8,10-dimethyl-11a-(1-methylethenyl)-7-oxo-2-(phenylmethyl)-7H-2,9b-epoxyazuleno[5,4-e]-1,3-benzodioxol-5-yl]benzeneacetate |
