CAS 59263-76-2|Meptazinol HCl

Introduction：Basic information about CAS 59263-76-2|Meptazinol HCl, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
4. Safety Information
5. Customs
6. Articles23
7. Synonyms

Common Name	Meptazinol HCl
CAS Number	59263-76-2	Molecular Weight	269.810
Density	/	Boiling Point	354.8ºC at 760 mmHg
Molecular Formula	C₁₅H₂₄ClNO	Melting Point	250-252ºC
MSDS	ChineseUSA	Flash Point	160.6ºC
Symbol	GHS07	Signal Word	Warning

Names

Name	Meptazinol Hydrochloride
Synonym	More Synonyms

Chemical & Physical Properties

Boiling Point	354.8ºC at 760 mmHg
Melting Point	250-252ºC
Molecular Formula	C₁₅H₂₄ClNO
Molecular Weight	269.810
Flash Point	160.6ºC
Exact Mass	269.154633
PSA	23.47000
LogP	3.89560
InChIKey	MPJUSISYVXABBH-UHFFFAOYSA-N
SMILES	CCC1(c2cccc(O)c2)CCCCN(C)C1.Cl
Storage condition	Desiccate at +4°C
Water Solubility	H2O: >10mg/mL

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SL4250000

CHEMICAL NAME :: Phenol, 3-(3-ethylhexahydro-1-methyl-1H-azepin-3-yl)-, hydrochloride

CAS REGISTRY NUMBER :: 59263-76-2

LAST UPDATED :: 199512

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C15-H23-N-O.Cl-H

MOLECULAR WEIGHT :: 269.85

WISWESSER LINE NOTATION :: T7NTJ A1 C2 CR CQ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1260 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year: 9,73,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 106 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year: 9,73,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 282 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year: 9,73,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 118 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year: 9,73,1978 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4550 mg/kg/26W-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

REFERENCE :: GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year: 9,73,1978

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Hazard Codes	Xn
Risk Phrases	22
RIDADR	NONH for all modes of transport
RTECS	SL4250000
HS Code	2942000000

Customs

HS Code	2942000000

Articles23

Bis(9)-(-)-nor-meptazinol as a novel dual-binding AChEI potently ameliorates scopolamine-induced cognitive deficits in mice.

Pharmacol. Biochem. Behav. 104 , 138-43, (2013)

Alzheimer's disease (AD) is a multifaceted neurodegenerative disorder which is characterized by the progressive deterioration of cognition and the emergence of behavioral and psychological symptoms in...

Reflex activity caused by laryngoscopy and intubation is obtunded differently by meptazinol, nalbuphine and fentanyl.

Eur. J. Anaesthesiol. 24(1) , 53-8, (2007)

To evaluate the different potencies of several opioids in obtunding reflex mechanisms of laryngoscopy and intubation.Three groups of patients (each n = 25, ASA 1-2) undergoing elective plastic surgery...

Lack of sensitization during place conditioning in rats is consistent with the low abuse potential of tramadol.

Neurosci. Lett. 329(1) , 25-8, (2002)

Based on the recent finding that tramadol (TRAM) produces conditioned place preference (CPP) and dopamine release in the nucleus accumbens, it was suggested that the abuse liability of TRAM may be gre...

Synonyms

Phenol, 3-(3-ethylhexahydro-1-methyl-1H-azepin-3-yl)-, hydrochloride (1:1)

3-(3-Ethyl-1-methylazepan-3-yl)phenol hydrochloride (1:1)

3-(3-ethyl-1-methylazepan-3-yl)phenol,hydrochloride

3-(3-Ethyl-1-methyl-3-azepanyl)phenol hydrochloride (1:1)

UNII:T62FQ4ZCPA

MEPTAZINOL HYDROCHLORIDE

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