CAS 60133-18-8|1-α,25-Dihydroxyvitamin D2

Introduction：Basic information about CAS 60133-18-8|1-α,25-Dihydroxyvitamin D2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 1-α,25-Dihydroxyvitamin D2 BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles116
6. Synonyms

Common Name	1-α,25-Dihydroxyvitamin D2
CAS Number	60133-18-8	Molecular Weight	428.647
Density	1.1±0.1 g/cm3	Boiling Point	577.7±50.0 °C at 760 mmHg
Molecular Formula	C₂₈H₄₄O₃	Melting Point	/
MSDS	ChineseUSA	Flash Point	242.5±24.7 °C
Symbol	GHS02, GHS07	Signal Word	Danger

Names

Name	1α,25-dihydroxyvitamin D2
Synonym	More Synonyms

1-α,25-Dihydroxyvitamin D2 BiologicalActivity

Description	Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is a active metabolite of vitamin D2. IC50 value: Target: Ercalcitriol (1α,25-Dihydroxy Vitamin D2) exhibits equipotent antirachitic activity in rats as calcitriol. Ercalcitriol(1α,25-Dihydroxy Vitamin D2) is a VDR-like Receptors
Related Catalog	Signaling Pathways >>Vitamin D Related >>VD/VDRResearch Areas >>Metabolic Disease
References	[1]. Mawer EB, Berry JL, Cundall JP, Still PE, White A.A sensitive radioimmunoassay using a monoclonal antibody that is equipotent for ercalcitriol and calcitriol (1,25-dihydroxy vitamin D2 and D3).Clin Chim Acta. 1990 Oct 15;190(3):199-209. [2]. Rambeck et al (1984) Biological activity of 1 alpha,25-dihydroxyergocalciferol in rachitic chicks and in rats. Int.J.Vitamin.Nutr.Res. 54 135. [3]. Shamik J. Parikh, Marni Edelman, Gabriel I. Uwaifo et al. The Relationship between Obesity and Serum 1,25-Dihydroxy Vitamin D Concentrations in Healthy Adults. The Journal of Clinical Endocrinology & Metabolism March 1, 2004 vol. 89 no. 3 1196-1199 [4]. Daniel W. Coyne, Marvin Grieff, Shubhada N. Ahya et al. Differential effects of acute administration of 19-Nor-1,25-dihydroxy-vitamin D2 and 1,25-dihydroxy-vitamin D3 on serum calcium and phosphorus in hemodialysis patients. American Journal of Kidney Diseases. December 2002,Volume 40, Issue 6 , Pages 1283-1288

Description

Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is a active metabolite of vitamin D2. IC50 value: Target: Ercalcitriol (1α,25-Dihydroxy Vitamin D2) exhibits equipotent antirachitic activity in rats as calcitriol. Ercalcitriol(1α,25-Dihydroxy Vitamin D2) is a VDR-like Receptors

Related Catalog

Signaling Pathways >>Vitamin D Related >>VD/VDRResearch Areas >>Metabolic Disease

References

[1]. Mawer EB, Berry JL, Cundall JP, Still PE, White A.A sensitive radioimmunoassay using a monoclonal antibody that is equipotent for ercalcitriol and calcitriol (1,25-dihydroxy vitamin D2 and D3).Clin Chim Acta. 1990 Oct 15;190(3):199-209.

[2]. Rambeck et al (1984) Biological activity of 1 alpha,25-dihydroxyergocalciferol in rachitic chicks and in rats. Int.J.Vitamin.Nutr.Res. 54 135.

[3]. Shamik J. Parikh, Marni Edelman, Gabriel I. Uwaifo et al. The Relationship between Obesity and Serum 1,25-Dihydroxy Vitamin D Concentrations in Healthy Adults. The Journal of Clinical Endocrinology & Metabolism March 1, 2004 vol. 89 no. 3 1196-1199

[4]. Daniel W. Coyne, Marvin Grieff, Shubhada N. Ahya et al. Differential effects of acute administration of 19-Nor-1,25-dihydroxy-vitamin D2 and 1,25-dihydroxy-vitamin D3 on serum calcium and phosphorus in hemodialysis patients. American Journal of Kidney Diseases. December 2002,Volume 40, Issue 6 , Pages 1283-1288

Chemical & Physical Properties

Density	1.1±0.1 g/cm3
Boiling Point	577.7±50.0 °C at 760 mmHg
Molecular Formula	C₂₈H₄₄O₃
Molecular Weight	428.647
Flash Point	242.5±24.7 °C
Exact Mass	428.329041
PSA	60.69000
LogP	6.15
Vapour Pressure	0.0±3.6 mmHg at 25°C
Index of Refraction	1.554
InChIKey	ZGLHBRQAEXKACO-XJRQOBMKSA-N
SMILES	C=C1C(=CC=C2CCCC3(C)C2CCC3C(C)C=CC(C)C(C)(C)O)CC(O)CC1O
Storage condition	−20°C

Safety Information

Symbol	GHS02, GHS07
Signal Word	Danger
Hazard Statements	H225-H319
Precautionary Statements	P210-P280-P305 + P351 + P338-P337 + P313-P403 + P235
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T: Toxic;
Risk Phrases	R23/24/25;R63
Safety Phrases	36/37-45
RIDADR	UN 2811
WGK Germany	3

Articles116

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Chem. Res. Toxicol. 23 , 171-83, (2010)

Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

J. Sci. Ind. Res. 65(10) , 808, (2006)

Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...

5-lipoxygenase is a direct target of miR-19a-3p and miR-125b-5p.

J. Immunol. 194(4) , 1646-53, (2015)

5-Lipoxygenase (5-LO) is the key enzyme in leukotriene biosynthesis. Leukotrienes are mediators of the innate immune system and inflammatory processes, and they might also be involved in cancer develo...

Synonyms

(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-6-hydroxy-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol

1α,25-dihydroxyergocalciferol

1alpha,25-dihydroxyvitamin D2

1α,25-Dihydroxy Vitamin D2

(1S,3R,5Z,7E,22E)-9,10-Secoergosta-5,7,10,22-tetraene-1,3,25-triol

1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,2E,4S)-5-hydroxy-1,4,5-trimethyl-2-hexen-1-yl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,3S,5Z)-

1α,25-Dihydroxycalciferol

Ercalcitriol

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