CAS 80448-90-4|Dynorphin A trifluoroacetate salt

Introduction：Basic information about CAS 80448-90-4|Dynorphin A trifluoroacetate salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Dynorphin A trifluoroacetate salt BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles3
6. Synonyms

Common Name	Dynorphin A trifluoroacetate salt
CAS Number	80448-90-4	Molecular Weight	2147.484
Density	1.5±0.1 g/cm3	Boiling Point	/
Molecular Formula	C₉₉H₁₅₅N₃₁O₂₃	Melting Point	/
MSDS	ChineseUSA	Flash Point	/

Names

Name	Dynorphin A
Synonym	More Synonyms

Dynorphin A trifluoroacetate salt BiologicalActivity

Description	Dynorphin A, an endogenous opioid peptide, is a highy potent kappa opioid receptor (KOR) activator. Dynorphin A also serve as an agonist for other opioid receptors, such as mu (MOR) and delta (DOR)[1].
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Opioid ReceptorSignaling Pathways >>Neuronal Signaling >>Opioid ReceptorResearch Areas >>Neurological Disease
References	[1]. Zhang, et al.Dynorphin A as a Potential Endogenous Ligand for Four Members of the Opioid Receptor Gene Family. J Pharmacol Exp Ther. 1998 Jul;286(1):136-41.

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Molecular Formula	C₉₉H₁₅₅N₃₁O₂₃
Molecular Weight	2147.484
Exact Mass	2146.191162
PSA	917.37000
LogP	-1.52
Index of Refraction	1.669
InChIKey	JMNJYGMAUMANNW-FIXZTSJVSA-N
SMILES	CCC(C)C(NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)C(N)Cc1ccc(O)cc1)C(=O)NC(CCCNC(=N)N)C(=O)N1CCCC1C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(=O)O)C(=O)NC(CC(N)=O)C(=O)NC(CCC(N)=O)C(=O)O
Storage condition	−20°C

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	22-24/25
RIDADR	NONH for all modes of transport
WGK Germany	3

Articles3

Dynorphin A as a potential endogenous ligand for four members of the opioid receptor gene family.

J. Pharmacol. Exp. Ther. 286 , 136-141, (1998)

Dynorphin A is an endogenous opioid peptide that activates the kappa opioid receptor (KOR) with high potency. Some studies also showed that the distribution and functional activity of dynorphin A are ...

Structure-activity relationship studies of dynorphin A and related peptides.

Peptides 19 , 1277-1292, (1998)

An up-to-date review is presented covering all the available information concerning the isolation, discovery, synthesis, conformation, receptor binding characteristics, pharmacological properties and ...

The kappa opioid receptor and dynorphin co-localize in vasopressin magnocellular neurosecretory neurons in guinea-pig hypothalamus.

Neuroscience 96 , 373-383, (2000)

The relationship between the cloned kappa opioid receptor, dynorphin, and the neurohypophysial hormones vasopressin and oxytocin was analysed in the guinea-pig hypothalamic magnocellular neurosecretor...

Synonyms

Dynorphin acetate

DYNORPHIN A PORCINE

L-Tyrosylglycylglycyl-L-phenylalanyl-L-leucyl-L-arginyl-L-arginyl-L-isoleucyl-L-arginyl-L-prolyl-L-lysyl-L-leucyl-L-lysyl-L-tryptophyl-L-α-aspartyl-L-asparaginyl-L-glutamine

YGGFLRRIRPKLKWDNQ

L-Glutamine, L-tyrosylglycylglycyl-L-phenylalanyl-L-leucyl-L-arginyl-L-arginyl-L-isoleucyl-L-arginyl-L-prolyl-L-lysyl-L-leucyl-L-lysyl-L-tryptophyl-L-α-aspartyl-L-asparaginyl-

DYNORPHIN A AMIDE

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