CAS 84-02-6|Prochlorperazine dimaleate

Introduction:Basic information about CAS 84-02-6|Prochlorperazine dimaleate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameProchlorperazine dimaleate
CAS Number84-02-6Molecular Weight606.08700
Density/Boiling Point524.8ºC at 760 mmHg
Molecular FormulaC28H32ClN3O8SMelting Point228ºC
MSDSChineseUSAFlash Point271.2ºC
Symbol
GHS07
Signal WordWarning

Names

Nameprochlorperazine maleate
SynonymMore Synonyms

Chemical & Physical Properties

Boiling Point524.8ºC at 760 mmHg
Melting Point228ºC
Molecular FormulaC28H32ClN3O8S
Molecular Weight606.08700
Flash Point271.2ºC
Exact Mass605.16000
PSA184.22000
LogP3.94460
InChIKeyZYSCHNVPUOSLNC-BTJKTKAUSA-N
SMILESCN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1.O=C(O)C=CC(=O)O
Storage conditionStore at RT
Water SolubilityVery slightly soluble in water and in ethanol (96 per cent).

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SO3150000
CAS REGISTRY NUMBER :
84-02-6
LAST UPDATED :
199703
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C20-H24-Cl-N3-S.2C4-H4-O4
MOLECULAR WEIGHT :
606.14
WISWESSER LINE NOTATION :
T C666 BN ISJ EG B3- AT6N DNTJ D1 &OV1U1VO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
600 ug/kg/18H-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - muscle contraction or spasticity
REFERENCE :
SMJOAV Southern Medical Journal. (Southern Medical Assoc., POB 2446, Birmingham, AL 35205) V.1- 1908- Volume(issue)/page/year: 84,407,1991
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 123,78,1959
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
191 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSYPAG Psychopharmacologia (Berlin). (Berlin, Ger.) V.1-46, 1959-76. For publisher information, see PSCHDL. Volume(issue)/page/year: 12,142,1968
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
320 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,40,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
85 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 12,445,1963 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5607 No. of Facilities: 84 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 4587 (estimated) No. of Female Employees: 4212 (estimated)

Safety Information

Symbol
GHS07
Signal WordWarning
Hazard StatementsH302 + H312 + H332
Precautionary StatementsP261-P280-P301 + P312 + P330
Personal Protective Equipmentdust mask type N95 (US);Eyeshields;Gloves
Hazard CodesXn: Harmful;
Risk PhrasesR20/21/22
Safety Phrases36
RIDADRNONH for all modes of transport
RTECSSO3150000
HS Code2934300000

Customs

HS Code2934300000
Summary2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Synonyms

stemetildimaleate
emetiral
Prochlorperazinbishydrogenmaleat
pasotomin
Prochlorperazine dimaleate,2-Chloro-10-[3[(4-methyl-1-piperazinyl)propyl]-10H-phenothiazinedimaleate
MFCD00069330
nibromina
Einecs 201-511-3
PROCHLORPERAZINE MALEATE
buctem
Prochlorperazine dimaleate
Vertigon
meterazinmaleate
PCZ-dimaleate
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