CAS 84379-13-5|Bretazenil

Introduction：Basic information about CAS 84379-13-5|Bretazenil, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
4. Safety Information
5. Articles28
6. Synonyms

Common Name	Bretazenil
CAS Number	84379-13-5	Molecular Weight	418.284
Density	1.6±0.1 g/cm3	Boiling Point	594.3±50.0 °C at 760 mmHg
Molecular Formula	C₁₉H₂₀BrN₃O₃	Melting Point	/
MSDS	ChineseUSA	Flash Point	313.2±30.1 °C

Names

Name	Bretazenil
Synonym	More Synonyms

Chemical & Physical Properties

Density	1.6±0.1 g/cm3
Boiling Point	594.3±50.0 °C at 760 mmHg
Molecular Formula	C₁₉H₂₀BrN₃O₃
Molecular Weight	418.284
Flash Point	313.2±30.1 °C
Exact Mass	417.068787
PSA	64.43000
LogP	2.52
Appearance of Characters	solid \| white
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.685
InChIKey	LWUDDYHYYNNIQI-ZDUSSCGKSA-N
SMILES	CC(C)(C)OC(=O)c1ncn2c1C1CCCN1C(=O)c1c(Br)cccc1-2
Storage condition	2-8°C
Water Solubility	DMSO: 24 mg/mL, soluble

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NJ5899850

CHEMICAL NAME :: 9H-Imidazo(1,5-a)pyrrolo(2,1-c)(1,4)benzodiazepine-1- carboxylic acid, 11,12,13,13a- tetrahydro-8-bromo-9-oxo-, 1,1-dimethylethyl ester, (S)-

CAS REGISTRY NUMBER :: 84379-13-5

LAST UPDATED :: 199806

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C19-H20-Br-N3-O3

MOLECULAR WEIGHT :: 418.33

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >312 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 13,730,1988

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	22-24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	NJ5899850

Articles28

A Comparison of the α2/3/5 Selective Positive Allosteric Modulators L-838,417 and TPA023 in Preclinical Models of Inflammatory and Neuropathic Pain.

Adv. Pharmacol. Sci. 2011 , 608912, (2011)

GABA(A) receptors containing α2/3 subunits are current targets in the battle to develop new pain medications, as they are expressed in the spinal cord where increasing inhibitory drive should result i...

A comparison of chlordiazepoxide, bretazenil, L838,417 and zolpidem in a validated mouse Vogel conflict test.

Psychopharmacology 182(4) , 475-84, (2005)

GABAA receptors containing an alpha2 subunit are proposed to mediate the anxiolytic effect of benzodiazepines (BZ) based on studies in transgenic mice using unconditioned models of anxiety. Conditione...

Contextual fear conditioning and baseline startle responses in the rat fear-potentiated startle test: a comparison of benzodiazepine/gamma-aminobutyric acid-A receptor agonists.

Behav. Pharmacol. 11(6) , 495-504, (2000)

In the rat, fear-potentiated startle (FPS) test animals are first trained to associate brief light presentations with a mild electric footshock and then tested for startle responses to acoustic stimul...

Synonyms

tert-Butyl (13aS)-8-bromo-9-oxo-11,12,13,13a-tetrahydro-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate

2-Methyl-2-propanyl (13aS)-8-bromo-9-oxo-11,12,13,13a-tetrahydro-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate

9H-Imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, 8-bromo-11,12,13,13a-tetrahydro-9-oxo-, 1,1-dimethylethyl ester, (13aS)-

Ro 16-6028

Ro-16-6028

tert-Butyl (S)-8-Bromo-11,12,13,13a-tetrahydro-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate

Bretazenil

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