CAS 93565-01-6|MDL 72527
| Common Name | MDL 72527 | ||
|---|---|---|---|
| CAS Number | 93565-01-6 | Molecular Weight | 265.22200 |
| Density | / | Boiling Point | 300.7ºC at 760mmHg |
| Molecular Formula | C12H22Cl2N2 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 159.2ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | N1,N4-Di(buta-2,3-dien-1-yl)butane-1,4-diamine dihydrochloride |
|---|---|
| Synonym | More Synonyms |
MDL 72527 BiologicalActivity
| Description | MDL 72527 dihydrochloride is a potent polyamine oxidase (PAO) inhibitor. MDL 72527 dihydrochloride shows a lysosomotropic effect. MDL 72527 dihydrochloride shows neuroprotective effects[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
| Target | polyamine oxidase (PAO)[1] |
| In Vitro | MDL 72527 dihydrochloride (300 µM; 24 h) 在 M14 WT 细胞中出现明显的形态学变化，出现大量溶酶体和大量细胞质空泡[2]。 Cell Cytotoxicity Assay[2] Cell Line: M14 cells Concentration: 300 µM Incubation Time: 24 h Result: Showed no significant effect on cell survival of melanoma cells. |
| In Vivo | MDL 72527 dihydrochloride (100 mg/kg; i.p.; once) 对暂时性局灶性脑缺血后的神经元细胞损伤具有神经保护作用[1]。 Animal Model: 250-300 g, Male spontaneously hypertensive rats (SHRs)[1] Dosage: 100 mg/kg Administration: I.p.; after the induction of ischemia Result: Significantly reduced meanarterial blood pressure, changed the brain edema formation from 85.7 ± 0.3 to 84.5 ± 0.9% in cortex and from 79.9 ± 1.7 to 78.4 ± 2.0% in subcortex (difference not significant), reduced ischemic injury volume by 22% in the cortex and 17% in the subcortex. |
| References | [1]. Doğan A, et al. Effects of MDL 72527, a specific inhibitor of polyamine oxidase, on brain edema, ischemic injury volume, and tissue polyamine levels in rats after temporary middle cerebral artery occlusion. J Neurochem. 1999 Feb;72(2):765-70. [2]. Agostinelli E, et al. Toxicity of enzymatic oxidation products of spermine to human melanoma cells (M14): sensitization by heat and MDL 72527. Biochim Biophys Acta. 2006 Oct;1763(10):1040-50. |
Chemical & Physical Properties
| Boiling Point | 300.7ºC at 760mmHg |
|---|---|
| Molecular Formula | C12H22Cl2N2 |
| Molecular Weight | 265.22200 |
| Flash Point | 159.2ºC |
| Exact Mass | 264.11600 |
| PSA | 24.06000 |
| LogP | 4.01380 |
| Index of Refraction | 1.536 |
| InChIKey | ITVRWVVFVHINOH-UHFFFAOYSA-N |
| SMILES | C=C=CCNCCCCNCC=C=C.Cl.Cl |
| Storage condition | 2-8°C |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2921290000 |
Customs
| HS Code | 2921290000 |
|---|---|
| Summary | 2921290000 other acyclic polyamines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
Articles24
More Articles| How important is the oxidative degradation of spermine?: minireview article. Amino Acids 26(4) , 317-9, (2004) Spermine is a constituent of most eucaryotic cells, however, it is not of vital importance for the vertebrate organism, as is demonstrated by the existence of transgenic (Gy) mice that lack spermine a... | |
| Polyamine metabolism is involved in adipogenesis of 3T3-L1 cells. Amino Acids 42(2-3) , 619-26, (2012) Polyamines spermidine and spermine are known to be required for mammalian cell proliferation and for embryonic development. Alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylas... | |
| Synergism between apple procyanidins and lysosomotropic drugs: potential in chemoprevention. Anticancer Res. 26(5A) , 3381-5, (2006) Procyanidins are apple constituents with potential in colon cancer chemoprevention.Human colon cancer derived metastatic cells (SW620), growing under standardized conditions, were exposed to procyanid... |
Synonyms
| N,N'-bis(buta-2,3-dienyl)butane-1,4-diamine,dihydrochloride |
