CAS 2260-08-4|Acetiromate

Introduction：Basic information about CAS 2260-08-4|Acetiromate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Acetiromate BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Synonyms

Common Name	Acetiromate
CAS Number	2260-08-4	Molecular Weight	649.94200
Density	2.351 g/cm3	Boiling Point	561.2ºC at 760 mmHg。产品描述安全性：
Molecular Formula	C₁₅H₉I₃O₅	Melting Point	/
MSDS	/	Flash Point	293.2ºC

Names

Name	4-(4-acetyloxy-3-iodophenoxy)-3,5-diiodobenzoic acid
Synonym	More Synonyms

Acetiromate BiologicalActivity

Description	Acetiromate is a thyroxine analogue. Acetiromate is an antilipidemic drug for hyperlipidemia[1].
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease
References	[1]. S Kumaoka. Long-term administration of 3,5-diodo-4(3'-iodo4'-acetoxyphenoxy) benzoic acid (acetiromate) in hyperlipidemic patients. Endocrinol Jpn. 1974 Aug;21(4):355-60.

Chemical & Physical Properties

Density	2.351 g/cm3
Boiling Point	561.2ºC at 760 mmHg。产品描述安全性：
Molecular Formula	C₁₅H₉I₃O₅
Molecular Weight	649.94200
Flash Point	293.2ºC
Exact Mass	649.75800
PSA	72.83000
LogP	4.91620
Vapour Pressure	1.96E-13mmHg at 25°C
Index of Refraction	1.724
InChIKey	AXVCIZJRCOHMQX-UHFFFAOYSA-N
SMILES	CC(=O)Oc1ccc(Oc2c(I)cc(C(=O)O)cc2I)cc1I

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG8597700

CHEMICAL NAME :: Benzoic acid, 3,5-diiodo-4-(4-hydroxy-3-iodophenoxy)-, acetate

CAS REGISTRY NUMBER :: 2260-08-4

LAST UPDATED :: 198706

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C15-H9-I3-O5

MOLECULAR WEIGHT :: 649.94

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 5,383,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 480 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 16,431,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 520 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 5,383,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 5,383,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 5,383,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 16,431,1974

Synonyms

Adecol

Acetyltriiodothyronine formic acid

TBF 43

Acetiromate

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