Introduction：Basic information about CAS 37561-27-6|Fenoverine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Fenoverine |
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| CAS Number | 37561-27-6 | Molecular Weight | 459.56 |
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| Density | 1.343g/cm3 | Boiling Point | 671.8ºC at 760mmHg |
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| Molecular Formula | C26H25N3O3S | Melting Point | / |
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| MSDS | / | Flash Point | 360.1ºC |
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Names
| Name | 2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-1-phenothiazin-10-ylethanone |
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| Synonym | More Synonyms |
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Fenoverine BiologicalActivity
| Description | Fenoverine is an antispasmodic drug and inhibits calcium channel currents[1]. Fenoverine induces rhabdomyolysis[2]. |
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| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Calcium ChannelResearch Areas >>Neurological Disease |
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| References | [1]. J Mironneau, et al. Fenoverine inhibition of calcium channel currents in single smooth muscle cells from rat portal vein and myometrium. Br J Pharmacol. 1991 Sep;104(1):65-70. [2]. Chung-Wen Chen, et al. Rhabdomyolysis induced by fenoverine: a case report and literature review. Acta Neurol Taiwan. 2005 Sep;14(3):143-6. |
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Chemical & Physical Properties
| Density | 1.343g/cm3 |
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| Boiling Point | 671.8ºC at 760mmHg |
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| Molecular Formula | C26H25N3O3S |
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| Molecular Weight | 459.56 |
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| Flash Point | 360.1ºC |
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| Exact Mass | 459.16200 |
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| PSA | 70.55000 |
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| LogP | 4.30320 |
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| Index of Refraction | 1.678 |
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| InChIKey | UBAJTZKNDCEGKL-UHFFFAOYSA-N |
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| SMILES | O=C(CN1CCN(Cc2ccc3c(c2)OCO3)CC1)N1c2ccccc2Sc2ccccc21 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- SN5445000
- CHEMICAL NAME :
- 10H-Phenothiazine, 10-((4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl)ace tyl)-
- CAS REGISTRY NUMBER :
- 37561-27-6
- LAST UPDATED :
- 199312
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C26-H25-N3-O3-S
- MOLECULAR WEIGHT :
- 459.60
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2874 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DECRDP Drugs under Experimental and Clinical Research. (Bioscience Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland) V.1- 1977- Volume(issue)/page/year: 15,37,1989
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Synonyms
| Fenoverine |
| Spasmopriv |
| EINECS 253-552-1 |
