Introduction：Basic information about CAS 88058-88-2|Naxagolide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Naxagolide |
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| CAS Number | 88058-88-2 | Molecular Weight | 247.333 |
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| Density | 1.1±0.1 g/cm3 | Boiling Point | 391.7±42.0 °C at 760 mmHg |
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| Molecular Formula | C15H21NO2 | Melting Point | / |
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| MSDS | / | Flash Point | 190.7±27.9 °C |
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Names
| Name | (4aR,10bR)-4-propyl-2,3,4a,5,6,10b-hexahydrobenzo[h][1,4]benzoxazin-9-ol |
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| Synonym | More Synonyms |
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Naxagolide BiologicalActivity
| Description | Naxagolide ((+)-PHNO; Dopazinol) is a potent dopamine D2 (Dopamine Receptor) agonist. Naxagolide has the potential for the research of parkinson's disease (PD)[1][2]. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Neurological Disease |
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| Target | D2 Receptor |
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| In Vitro | 在体外，Naxagolide ((+)-PHNO) 抑制大鼠纹状体膜上的 [3H]apomorphine (IC50 = 23 nM) 或 [3 H]spiperone (IC50 = 55 nM)[1]。 |
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| In Vivo | 在小鼠中，Naxagolide ((+)-PHNO) 在单侧尾部切除的动物中产生体温过低 (13 μg/kg i.p.) 和姿势不对称 (4 μg/kg i.p.)[1]。 在大鼠中，Naxagolide ((+)-PHNO) 在 6-羟基多巴胺损伤的动物中产生刻板印象（10 μg/kg i.p.）和对侧转向（5 μg/kg i.p.），持续 1 至 3 小时[1] 。 |
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| References | [1]. G E Martin, et al. Pharmacologic profile of a novel potent direct-acting dopamine agonist, (+)-4-propyl-9-hydroxynaphthoxazine [(+)-PHNO]. J Pharmacol Exp Ther. 1984 Sep;230(3):569-76. [2]. E F Domino, et al. Relative potency and efficacy of some dopamine agonists with varying selectivities for D1 and D2 receptors in MPTP-induced hemiparkinsonian monkeys. J Pharmacol Exp Ther. 1993 Jun;265(3):1387-91. |
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Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
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| Boiling Point | 391.7±42.0 °C at 760 mmHg |
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| Molecular Formula | C15H21NO2 |
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| Molecular Weight | 247.333 |
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| Flash Point | 190.7±27.9 °C |
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| Exact Mass | 247.157227 |
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| PSA | 32.70000 |
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| LogP | 2.55 |
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| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
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| Index of Refraction | 1.553 |
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| InChIKey | JCSREICEMHWFAY-HUUCEWRRSA-N |
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| SMILES | CCCN1CCOC2c3cc(O)ccc3CCC21 |
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Safety Information
Customs
| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| (+)-PHNO |
| 4-Propyl-9-hydroxy-1,2,3,4a,5,6-hexahydronaphthoxazine |
| (+)-trans-1a,2,3,4a,5,6-Hexahydro-9-hydroxy-4-propyl-4H-naphth-[1,2-b]-1,4-oxazine |
| Naxagolida |
| dopazinol |
| (4aR,10bR)-4-Propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol |
| Naxagolide |
| (+)-4-Propyl-9-hydroxynaphthoxazine |
| 2H-Naphth[1,2-b]-1,4-oxazin-9-ol, 3,4,4a,5,6,10b-hexahydro-4-propyl-, (4aR,10bR)- |
| (4aR)-trans-3,4,4a,5,6,10b-Hexahydro-4-propyl-2H-naphth[1,2-b]-1,4-oxazin-9-ol |
| PHNO |
