Introduction：Basic information about CAS 170787-99-2|Efaproxiral sodium, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Efaproxiral sodium |
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| CAS Number | 170787-99-2 | Molecular Weight | 363.383 |
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| Density | / | Boiling Point | 554.5ºC at 760mmHg |
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| Molecular Formula | C20H22NNaO4 | Melting Point | / |
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| MSDS | / | Flash Point | 289.2ºC |
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Names
| Name | sodium,2-[4-[2-(3,5-dimethylanilino)-2-oxoethyl]phenoxy]-2-methylpropanoate |
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| Synonym | More Synonyms |
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Efaproxiral sodium BiologicalActivity
| Description | Efaproxiral sodium is a synthetic allosteric modifier of haemoglobin (Hb), decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy.in vitro: Efaproxiral increases oxygen levels in hypoxic tumor tissues by binding non-covalently to the hemoglobin tetramer and decreasing hemoglobin-oxygen binding affinity. Increasing tumor oxygenation reduces tumor radioresistance. Efaproxiral can enhance the oxygenation of hypoxic tumours and function as a radiation sensitiser, increasing the effectiveness of RT. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Cancer |
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| References | [1]. Stea B, et al. Efaproxiral red blood cell concentration predicts efficacy in patients with brain metastases. Br J Cancer. 2006 Jun 19;94(12):1777-1784. |
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Chemical & Physical Properties
| Boiling Point | 554.5ºC at 760mmHg |
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| Molecular Formula | C20H22NNaO4 |
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| Molecular Weight | 363.383 |
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| Flash Point | 289.2ºC |
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| Exact Mass | 363.144653 |
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| PSA | 78.46000 |
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| LogP | 2.46490 |
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| Vapour Pressure | 3.93E-13mmHg at 25°C |
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| InChIKey | SWDPIHPGORBMFR-UHFFFAOYSA-M |
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| SMILES | Cc1cc(C)cc(NC(=O)Cc2ccc(OC(C)(C)C(=O)[O-])cc2)c1.[Na+] |
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| Storage condition | 2-8°C |
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Safety Information
| Hazard Codes | Xi |
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| HS Code | 2924299090 |
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Customs
| HS Code | 2924299090 |
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| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| Efaproxiral sodium |
| Revaproxyn |
| RSR-13 |
| Sodium 2-(4-{2-[(3,5-dimethylphenyl)amino]-2-oxoethyl}phenoxy)-2-methylpropanoate |
| RSR 13 sodium |
| Propanoic acid, 2-[4-[2-[(3,5-dimethylphenyl)amino]-2-oxoethyl]phenoxy]-2-methyl-, sodium salt (1:1) |
| Efaproxiral (sodium) |
