CAS 483-63-6|Crotamiton

Introduction：Basic information about CAS 483-63-6|Crotamiton, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Crotamiton BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Articles25
7. Synonyms

Common Name	Crotamiton
CAS Number	483-63-6	Molecular Weight	203.280
Density	1.0±0.1 g/cm3	Boiling Point	282.7±19.0 °C at 760 mmHg
Molecular Formula	C₁₃H₁₇NO	Melting Point	/
MSDS	ChineseUSA	Flash Point	115.5±12.7 °C
Symbol	GHS07	Signal Word	Warning

Names

Name	crotamiton
Synonym	More Synonyms

Crotamiton BiologicalActivity

Description	Crotamiton is a drug that is used both as a scabicidal (for treating scabies) and as a general antipruritic. It is a prescription lotion based medicine that is applied to the whole body to get rid of the scabies parasite.
Related Catalog	Signaling Pathways >>Anti-infection >>ParasiteResearch Areas >>Infection

Chemical & Physical Properties

Density	1.0±0.1 g/cm3
Boiling Point	282.7±19.0 °C at 760 mmHg
Molecular Formula	C₁₃H₁₇NO
Molecular Weight	203.280
Flash Point	115.5±12.7 °C
Exact Mass	203.131012
PSA	20.31000
LogP	3.10
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.552

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GQ7000000

CHEMICAL NAME :: o-Crotonotoluidide, N-ethyl-

CAS REGISTRY NUMBER :: 483-63-6

BEILSTEIN REFERENCE NO. :: 3275497

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C13-H17-N-O

MOLECULAR WEIGHT :: 203.31

WISWESSER LINE NOTATION :: 2U1VN2&R B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,35,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 318 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,233,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1630 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,233,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,35,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 395 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,233,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1393 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,233,1982

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H317-H319
Precautionary Statements	P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R22
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	GQ7000000

Articles25

Triple allergic contact sensitivities due to ferbinac, crotamiton and diisopropanolamine.

Contact Dermatitis 49(5) , 261-3, (2003)

Hydrophilic anthropogenic markers for quantification of wastewater contamination in ground- and surface waters.

Environ. Toxicol. Chem. 28(12) , 2528-36, (2009)

Hydrophilic, persistent markers are useful to detect, locate, and quantify contamination of natural waters with domestic wastewater. The present study focused on occurrence and fate of seven marker ca...

[Treatment of rosacea].

Ann. Dermatol. Venereol. 138 Suppl 2 , S158-62, (2011)

A range of treatment options are available in rosacea, which include several topical (mainly metronidazole, azelaic acid, other antibiotics, sulfur, retinoids) and oral drugs (mainly tetracyclines, me...

Synonyms

2-Butenamide, N-ethyl-N-(2-methylphenyl)-, (2E)-

N-Ethyl-o-Crotonotoluidine (Crotamiton)

N-Ethyl-o-crotonotoluidide,Crotamiton

(2E)-N-Ethyl-N-(2-methylphenyl)-2-butenamide

N-Ethyl-o-crotonotoluidide

(2E)-N-ethyl-N-(2-methylphenyl)but-2-enamide

MFCD00026989

N-ethylcrotono-o-toluidide

Crotamiton

EINECS 207-596-3

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