Introduction：Basic information about CAS 529-61-3|Euxanthone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Euxanthone |
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| CAS Number | 529-61-3 | Molecular Weight | 228.200 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 472.6±45.0 °C at 760 mmHg |
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| Molecular Formula | C13H8O4 | Melting Point | / |
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| MSDS | / | Flash Point | 191.1±22.2 °C |
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Names
| Name | euxanthone |
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| Synonym | More Synonyms |
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Euxanthone BiologicalActivity
| Description | Euxanthone, a xanthone derivative, attenuates Aβ1-42-induced oxidative stress and apoptosis by triggering Autophagy. Euxanthone exhibits anti-neoplastic and neuroprotective activities[1][2][3]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Autophagy >>AutophagyResearch Areas >>Neurological Disease |
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| In Vitro | Euxanthone (10-20 μM; 24 h) 损害 OS 细胞以剂量依赖方式迁移的能力，并显着抑制细胞侵袭。Euxanthone 显着降低与纤连蛋白的粘附[1]。 Euxanthone (10-20 μM; 24 h) 通过 miR-21/PDCD4/c-jun 信号通路调节 COX-2 的表达。Euxanthone 对 COX-2 的抑制介导了其抗转移活性[1]。 Cell Migration Assay [1] Cell Line: Osteosarcoma (OS) cells Concentration: 10 μM, 20 μM Incubation Time: 24 h Result: Inhibited cell migration at 24 hr. Western Blot Analysis[1] Cell Line: Osteosarcoma (OS) cells Concentration: 10 μM, 20 μM Incubation Time: 24 h Result: Repressed both the mRNA and protein level of COX-2 in OS cells in a dose-dependent fashion. |
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| In Vivo | 在肺转移模型中，Euxanthone (40-80 mg/kg) 可显着减少肺组织中转移结节的数量[1]。 Euxanthone（30-60 mg/kg；口服；每天一次；持续 7 天）治疗使双侧颈总动脉闭塞的小鼠 Bnip3、Beclin1、Pink1、Parkin、p53、Bax、caspase-3 和 LC3 II/I 正常化。Euxanthone 调节由线粒体断裂介导的线粒体应激诱导的线粒体自噬和细胞凋亡[2]。 Animal Model: Forty male ICR mice (20 g) induced cerebral ischemia and reperfusion[2] Dosage: 30 mg/kg, 60 mg/kg Administration: p.o.;once a day; for 7 days Result: Markedly attenuated BCCAO triggered mitochondrial stress and related breakdown. |
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| References | [1]. Xiaodong Chen, et al. Euxanthone Impairs the Metastatic Potential of Osteosarcoma by Reducing COX-2 Expression. Anat Rec (Hoboken). 2019 Aug;302(8):1399-1408. [2]. Wei Sun, et al. Euxanthone improves cognitive impairment by attenuating mitochondrial fragmentation and suppressing oxidative stress. Cent Eur J Immunol. 2021;46(4):446-455. [3]. aicheng Yuan, et al. Euxanthone Attenuates Aβ1-42-Induced Oxidative Stress and Apoptosis by Triggering Autophagy. J Mol Neurosci. 2018 Dec;66(4):512-523. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 472.6±45.0 °C at 760 mmHg |
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| Molecular Formula | C13H8O4 |
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| Molecular Weight | 228.200 |
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| Flash Point | 191.1±22.2 °C |
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| Exact Mass | 228.042252 |
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| PSA | 70.67000 |
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| LogP | 1.92 |
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| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
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| Index of Refraction | 1.718 |
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| InChIKey | KDXFPEKLLFWHMN-UHFFFAOYSA-N |
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| SMILES | O=c1c2cc(O)ccc2oc2cccc(O)c12 |
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Safety Information
Customs
| HS Code | 2932999099 |
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| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 1,7-Dihydroxy-9H-xanthen-9-one |
| 1,7-dihydroxyxanthen-9-one |
| purrenone |
| 1,7-Dihydroxyxanthone |
| eyxanthone |
| Euxanthone |
| 1,7-Dihydroxy-xanthen-9-on |
| 1,7-dihydroxy-xanthen-9-one |
| 9H-Xanthen-9-one, 1,7-dihydroxy- |
