CAS 17650-86-1|Amicetin

Introduction：Basic information about CAS 17650-86-1|Amicetin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Amicetin BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Synonyms

Common Name	Amicetin
CAS Number	17650-86-1	Molecular Weight	618.67900
Density	1.46g/cm3	Boiling Point	/
Molecular Formula	C₂₉H₄₂N₆O₉	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	Benzamide,4-[[(2S)-2-amino-3-hydroxy-2-methyl-1-oxopropyl]amino]-N-[1-[(2R,5S,6R)-5-[[4,6-dideoxy-4-(dimethylamino)-a-D-glucopyranosyl]oxy]tetrahydro-6-methyl-2H-pyran-2-yl]-1,2-dihydro-2-oxo-4-pyrimidinyl]
Synonym	More Synonyms

Amicetin BiologicalActivity

Description	Amicetin is a potent antibiotic. Amicetin shows antibiotic activities against gram-positive bacteria. Amicetin inhibits protein synthesis[1][2][3].
Related Catalog	Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial
References	[1]. HINUMA Y, et al. An amicetin (sacromycin) from Streptomyces sp. No. 5223. Studies on Streptomyces antibiotics. XXXVI. J Antibiot (Tokyo). 1955 Nov;8(5):148-52. [2]. Fu, J., et al. Total Synthesis of Nucleoside Antibiotics Amicetin, Plicacetin, and Cytosaminomycin A—D. Chinese Journal of Chemistry, 2021, 39(10), 2679-2684. [3]. Ennis, H. L. et, al. Polysome Metabolism in Escherichia coli: Amicetin, an Antibiotic That Stabilizes Polysomes. Antimicrobial Agents and Chemotherapy, 1972, 1(3), 204-209. doi:10.1128/aac.1.3.204.

Description

Amicetin is a potent antibiotic. Amicetin shows antibiotic activities against gram-positive bacteria. Amicetin inhibits protein synthesis[1][2][3].

Related Catalog

Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial

References

[1]. HINUMA Y, et al. An amicetin (sacromycin) from Streptomyces sp. No. 5223. Studies on Streptomyces antibiotics. XXXVI. J Antibiot (Tokyo). 1955 Nov;8(5):148-52.

[2]. Fu, J., et al. Total Synthesis of Nucleoside Antibiotics Amicetin, Plicacetin, and Cytosaminomycin A—D. Chinese Journal of Chemistry, 2021, 39(10), 2679-2684.

[3]. Ennis, H. L. et, al. Polysome Metabolism in Escherichia coli: Amicetin, an Antibiotic That Stabilizes Polysomes. Antimicrobial Agents and Chemotherapy, 1972, 1(3), 204-209. doi:10.1128/aac.1.3.204.

Chemical & Physical Properties

Density	1.46g/cm3
Molecular Formula	C₂₉H₄₂N₆O₉
Molecular Weight	618.67900
Exact Mass	618.30100
PSA	210.73000
LogP	0.46960
Index of Refraction	1.651
InChIKey	HDNVYHWHCVTDIV-UHFFFAOYSA-N
SMILES	CC1OC(n2ccc(NC(=O)c3ccc(NC(=O)C(C)(N)CO)cc3)nc2=O)CCC1OC1OC(C)C(N(C)C)C(O)C1O

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BE5950000

CHEMICAL NAME :: Amicetin

CAS REGISTRY NUMBER :: 17650-86-1

BEILSTEIN REFERENCE NO. :: 0102092

LAST UPDATED :: 199612

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C29-H42-N6-O9

MOLECULAR WEIGHT :: 618.77

WISWESSER LINE NOTATION :: T6OTJ CQ DN1&1 F1Q BO- DT5OTJ B1 E1 B- AT6NVNJ DMVR DMVXZ1&1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 530 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 57 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 14 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Protozoa - Euglena gracilis

DOSE/DURATION :: 1500 mg/L

REFERENCE :: NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4- 1957- Volume(issue)/page/year: 19,579,1972

Synonyms

amicetin

Amicetin-A

Recommended......