CAS 7493-95-0|4-Nitrophenyl α-D-galactopyranoside
| Common Name | 4-Nitrophenyl α-D-galactopyranoside | ||
|---|---|---|---|
| CAS Number | 7493-95-0 | Molecular Weight | 301.249 |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 582.2±50.0 °C at 760 mmHg |
| Molecular Formula | C12H15NO8 | Melting Point | 166-169ºC |
| MSDS | USA | Flash Point | 305.9±30.1 °C |
Names
| Name | 4-nitrophenyl-α-D-galactoside |
|---|---|
| Synonym | More Synonyms |
4-Nitrophenyl α-D-galactopyranoside BiologicalActivity
| Description | 4-Nitrophenyl α-D-galactopyranoside (PNP-alpha-D-Gal) is an artificial substrate of 4-nitrophenyl (pNP) glycopyranoside for detecting α-galactosidase activity. The amount of released pNP is significantly increased when 4-Nitrophenyl α-D-galactopyranoside is used as substrates[1]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
| In Vitro | Using 4-nitorophenol (pNP)-glycopyranosides as pseudosubstrates, the amount of liberated pNP from the 4-Nitrophenyl α-D-galactopyranoside is significantly higher than that from the other pNP-glycopyranosides at pH 4.0 whereas no activity was detected at pH 7.0[1]. The digestion assays using 4-nitrophenyl (pNP) glycopyranosides as artificial substrates shows that yieldin liberated galactose residues from 4-Nitrophenyl α-D-galactopyranoside mainly at pH 4.0, i.e. the pH level where yield threshold is decreased at most[1]. |
| References | [1]. Okamoto-Nakazato A. Implications of the galactosidase activity of yieldin in the regulatory mechanism of yield threshold that is fundamental to cell wall extension. Physiol Plant. 2018 Jun;163(2):259-266. |
Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 582.2±50.0 °C at 760 mmHg |
| Melting Point | 166-169ºC |
| Molecular Formula | C12H15NO8 |
| Molecular Weight | 301.249 |
| Flash Point | 305.9±30.1 °C |
| Exact Mass | 301.079773 |
| PSA | 145.20000 |
| LogP | -0.55 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.648 |
| InChIKey | IFBHRQDFSNCLOZ-IIRVCBMXSA-N |
| SMILES | O=[N+]([O-])c1ccc(OC2OC(CO)C(O)C(O)C2O)cc1 |
| Storage condition | 2-8°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | 36/37/38 |
| Safety Phrases | 22-24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles28
More Articles| The galactophilic lectin, LecA, contributes to biofilm development in Pseudomonas aeruginosa. Environ. Microbiol. 8(6) , 1095-104, (2006) LecA (PA-IL) is a cytotoxic lectin and adhesin produced by Pseudomonas aeruginosa which binds hydrophobic galactosides with high specificity and affinity. By using a lecA-egfp translation fusion and i... | |
| Cryptosporidium p30, a galactose/N-acetylgalactosamine-specific lectin, mediates infection in vitro. J. Biol. Chem. 282 , 34877-87, (2007) Cryptosporidium sp. cause human and animal diarrheal disease worldwide. The molecular mechanisms underlying Cryptosporidium attachment to, and invasion of, host cells are poorly understood. Previously... | |
| Binding of hydrophobic D-galactopyranosides to the lactose permease of Escherichia coli. Biochemistry 41(43) , 13039-45, (2002) Binding of alpha- and beta-D-galactopyranosides with different hydrophobic aglycons was compared using substrate protection against N-ethylmaleimide alkylation of single-Cys148 lactose permease. As de... |
Synonyms
| 4-nitrophenyl-alpha-D-galactoside |
| 4-Nitrophenyl β-D-galactopyranoside |
| 1-O-[P-NITROPHENYL]-β-D-GALACTOPYRANOSE |
| β-D-Galactopyranoside, 4-nitrophenyl (9CI) |
| β-D-Galactopyranoside, 4-nitrophenyl |
| MFCD00065050 |
| p-Nitrophenyl .α.-D-galactopyranoside |
| α-D-Galactopyranoside, 4-nitrophenyl |
| p-Nitrophenyl α-D-galactopyranoside |
| 4-Nitrophenyl α-D-galactopyranoside |
| EINECS 231-343-6 |
| p-Nitrophenyl β-D-galactopyranoside |
| 4-Nitrophenyl a-D-galactopyranoside |
