Introduction：Basic information about CAS 567-02-2|THDOC, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | THDOC |
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| CAS Number | 567-02-2 | Molecular Weight | 334.49300 |
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| Density | 1.115g/cm3 | Boiling Point | 470.3ºC at 760mmHg |
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| Molecular Formula | C21H34O3 | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | 252.3ºC |
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Names
| Name | 2-hydroxy-1-[(8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone |
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| Synonym | More Synonyms |
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THDOC BiologicalActivity
| Description | 3α,21-Dihydroxy-5α-pregnan-20-one (THDOC), an endogenous neurosteroid, is a positive modulator of GABAA receptors. 3α,21-Dihydroxy-5α-pregnan-20-one potentiates neuronal response to low concentrations of GABA at α4β1δ GABAA receptors in vitro. |
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| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>GABA ReceptorSignaling Pathways >>Neuronal Signaling >>GABA Receptor |
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Chemical & Physical Properties
| Density | 1.115g/cm3 |
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| Boiling Point | 470.3ºC at 760mmHg |
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| Molecular Formula | C21H34O3 |
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| Molecular Weight | 334.49300 |
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| Flash Point | 252.3ºC |
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| Exact Mass | 334.25100 |
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| PSA | 57.53000 |
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| LogP | 3.56760 |
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| Index of Refraction | 1.54 |
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| InChIKey | CYKYBWRSLLXBOW-GDYGHMJCSA-N |
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| SMILES | CC12CCC(O)CC1CCC1C2CCC2(C)C(C(=O)CO)CCC12 |
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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Articles32
More Articles
| Chemical genetics reveals a complex functional ground state of neural stem cells. Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc... | |
| A quantitiative LC-MS/MS method for the measurement of arachidonic acid, prostanoids, endocannabinoids, N-acylethanolamines and steroids in human plasma. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 976-977 , 6-18, (2015) Free arachidonic acid is functionally interlinked with different lipid signaling networks including those involving prostanoid pathways, the endocannabinoid system, N-acylethanolamines, as well as ste... | |
| Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nat. Chem. Biol. 5 , 765-71, (2009) Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened... | |
Synonyms
| [3H]-Allotetrahydrodeoxycorticosterone |
| 21-HYDROXYALLOPREGNANOLONE |
| TDOC |
| ALLOTETRADEOXYCORTICOSTERONE |
| ALLOTETRAHYDRO DOC |
| ALLOTETRAHYDRO SUBSTANCE 'Q' |
| ALLOTETRAHYDRODEOXYCORTICOSTERONE |
| ALLOTETRAHYDROCORTEXONE |
| ALLO TH DOC |
| 5A-pregnane-3A,21-diol-20-one |
