CAS 52-39-1|aldosterone
| Common Name | aldosterone | ||
|---|---|---|---|
| CAS Number | 52-39-1 | Molecular Weight | 360.444 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 568.1±50.0 °C at 760 mmHg |
| Molecular Formula | C21H28O5 | Melting Point | 170-172ºC |
| MSDS | ChineseUSA | Flash Point | 311.4±26.6 °C |
| Symbol | GHS02, GHS07 | Signal Word | Danger |
Names
| Name | aldosterone |
|---|---|
| Synonym | More Synonyms |
aldosterone BiologicalActivity
| Description | Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level[1][2]. |
|---|---|
| Related Catalog | Research Areas >>Cardiovascular Disease |
| Target | Human Endogenous Metabolite |
| In Vitro | Aldosterone (1-1000 nM; 24 hours) inhibits interleukin-1β-stimulated nitrite production by vascular smooth muscle cells in a dose-dependent manner[3]. |
| In Vivo | Aldosterone (1 mg/Kg+1% NaCl; i.h.; once daily for 3 weeks) significantly increases systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular systolic pressure (LVSP) and left ventricular end-diastolic pressure (LVEDP)[4]. Aldosterone (0.72 mg/kg/day; 14 days) causes a small increase ( 14 mmHg) in blood pressure in male mice[5]. Animal Model: Forty male Wistar rats[4] Dosage: 1 mg/Kg (+1% NaCl) Administration: i.h.; once daily for 3 weeks Result: Systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular systolic pressure (LVSP) and left ventricular end-diastolic pressure (LVEDP) were significantly higher in aldosterone-salt-treated animals. |
| References | [1]. Nanba K, et al. Aging and Adrenal Aldosterone Production. Hypertension. 2018 Feb;71(2):218-223. [2]. Cannavo A, et al. Aldosterone and Mineralocorticoid Receptor System in Cardiovascular Physiology and Pathophysiology. Oxid Med Cell Longev. 2018 Sep 19;2018:1204598. [3]. Ikeda U, et al. Aldosterone inhibits nitric oxide synthesis in rat vascular smooth muscle cells induced by interleukin-1 beta. Eur J Pharmacol. 1995 Jul 18;290(2):69-73. [4]. Martín-Fernández B, et al. Beneficial effects of proanthocyanidins in the cardiac alterations induced by aldosterone in ratheart through mineralocorticoid receptor blockade. PLoS One. 2014 Oct 29;9(10):e111104. [5]. Dinh QN, et al. Aldosterone-induced oxidative stress and inflammation in the brain are mediated by the endothelial cell mineralocorticoid receptor. Brain Res. 2016 Apr 15;1637:146-153. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 568.1±50.0 °C at 760 mmHg |
| Melting Point | 170-172ºC |
| Molecular Formula | C21H28O5 |
| Molecular Weight | 360.444 |
| Flash Point | 311.4±26.6 °C |
| Exact Mass | 360.193665 |
| PSA | 91.67000 |
| LogP | 0.73 |
| Vapour Pressure | 0.0±3.5 mmHg at 25°C |
| Index of Refraction | 1.586 |
| InChIKey | PQSUYGKTWSAVDQ-ZVIOFETBSA-N |
| SMILES | CC12CCC(=O)C=C1CCC1C2C(O)CC2(C=O)C(C(=O)CO)CCC12 |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- DNA damage
MUTATION DATA - TEST SYSTEM :
- Rodent - rat
- DOSE/DURATION :
- 23 mg/kg
- REFERENCE :
- PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 141,14,1972 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3853 No. of Facilities: 46 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 279 (estimated) No. of Female Employees: 46 (estimated)
- TEST SYSTEM :
- Rodent - rat
- DOSE/DURATION :
- 23 mg/kg
- REFERENCE :
- PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 141,14,1972 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3853 No. of Facilities: 46 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 279 (estimated) No. of Female Employees: 46 (estimated)
Safety Information
| Symbol | GHS02, GHS07 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H302 + H312 + H332-H319 |
| Precautionary Statements | P210-P280-P305 + P351 + P338 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | 22-24/25-36-26 |
| RIDADR | UN 1648 3 / PGII |
| WGK Germany | 3 |
| RTECS | TU4523000 |
| HS Code | 29372900 |
Customs
| HS Code | 29372900 |
|---|
Articles284
More Articles| Cistrome of the aldosterone-activated mineralocorticoid receptor in human renal cells. FASEB J. 29 , 3977-89, (2015) Aldosterone exerts its effects mainly by activating the mineralocorticoid receptor (MR), a transcription factor that regulates gene expression through complex and dynamic interactions with coregulator... | |
| Finerenone Impedes Aldosterone-dependent Nuclear Import of the Mineralocorticoid Receptor and Prevents Genomic Recruitment of Steroid Receptor Coactivator-1. J. Biol. Chem. 290 , 21876-89, (2015) Aldosterone regulates sodium homeostasis by activating the mineralocorticoid receptor (MR), a member of the nuclear receptor superfamily. Hyperaldosteronism leads todeleterious effects on the kidney, ... | |
| Sodium homeostasis is preserved in a global 11β-hydroxysteroid dehydrogenase type 1 knockout mouse model. Exp. Physiol. 100 , 1362-78, (2015) What is the central question of this study? Glucocorticoids act in the kidney to promote salt and water retention. Renal 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1), by increasing local concentr... |
Synonyms
| 11β,21-Dihydroxy-3,20-dioxo-pregn-4-en-18-al |
| Pregn-4-en-18-al, 11,21-dihydroxy-3,20-dioxo-, (11β)- |
| (11β)-11,21-dihydroxy-3,20-dioxo-Pregn-4-en-18-al |
| Aldocorten |
| Aldocortene |
| (11b)-11,21-dihydroxy-3,20-dioxo-pregn-4-en-18-al |
| 11-β,21-Dihydroxy-3,20-dioxopregn-4-en-18-al |
| Aldocortin |
| MFCD00051136 |
| Aldosterone |
| (11β)-11,21-Dihydroxy-3,20-dioxopregn-4-en-18-al |
| d-Aldosterone |
| 18-Oxocorticosterone |
| (11b)-11,21-Dihydroxy-3,20-dioxopregn-4-en-18-al |
| 18-Formyl-11b,21-dihydroxy-4-pregnene-3,20-dione |
| 11b,21-dihydroxy-3,20-dioxo-pregn-4-en-18-al |
| 11β,21-Dihydroxypregn-4-ene-3,18,20-trione |
| (8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-13-carbaldehyde |
| Reichstein X |
| Elektrocortin |
| 4-pregnen-11,21-diol-3,20-dione-18-al |
| EINECS 200-139-9 |
| Electrocortin |
