CAS 56595-54-1|D-(2-2H)Alanine

Introduction：Basic information about CAS 56595-54-1|D-(2-2H)Alanine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. D-(2-2H)Alanine BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	D-(2-2H)Alanine
CAS Number	56595-54-1	Molecular Weight	90.10
Density	1.2±0.1 g/cm3	Boiling Point	212.9±23.0 °C at 760 mmHg
Molecular Formula	C₃H₆DNO₂	Melting Point	/
MSDS	/	Flash Point	82.6±22.6 °C

Names

Name	d-alanine-2-d1
Synonym	More Synonyms

D-(2-2H)Alanine BiologicalActivity

Description	D-Alanine-d1 is the deuterium labeled D-Alanine. D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR[1].
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Schmieden V, et al. Pharmacology of the inhibitory glycine receptor: agonist and antagonist actions of amino acids and piperidine carboxylic acid compounds. Mol Pharmacol. 1995 Nov;48(5):919-27. [3]. Saitoh T, et al. A novel antagonist, phenylbenzene omega-phosphono-alpha-amino acid, for strychnine-sensitive glycine receptors in the rat spinal cord. Br J Pharmacol. 1994 Sep;113(1):165-70.

Description

D-Alanine-d1 is the deuterium labeled D-Alanine. D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Schmieden V, et al. Pharmacology of the inhibitory glycine receptor: agonist and antagonist actions of amino acids and piperidine carboxylic acid compounds. Mol Pharmacol. 1995 Nov;48(5):919-27.

[3]. Saitoh T, et al. A novel antagonist, phenylbenzene omega-phosphono-alpha-amino acid, for strychnine-sensitive glycine receptors in the rat spinal cord. Br J Pharmacol. 1994 Sep;113(1):165-70.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	212.9±23.0 °C at 760 mmHg
Molecular Formula	C₃H₆DNO₂
Molecular Weight	90.10
Flash Point	82.6±22.6 °C
Exact Mass	90.053955
PSA	63.32000
LogP	-0.68
Vapour Pressure	0.1±0.9 mmHg at 25°C
Index of Refraction	1.460
InChIKey	QNAYBMKLOCPYGJ-LIIDHCAMSA-N
SMILES	CC(N)C(=O)O
Storage condition	-20C

Synonyms

D-Glucose-6,6-2H2

6,6-dideuterio-D-glucose

Dextrose-6,6-d2

D-Alanine-2-d

2-deutero-D-alanine

D-Glucose-6-d2

D-<6,6-D2>Glucose

6,6-Dideuterioglucose

D-(2-H)Alanine

D-Glucose-6,6-d2

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