Introduction：Basic information about CAS 56-69-9|5-Hydroxytryptophan, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 5-Hydroxytryptophan |
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| CAS Number | 56-69-9 | Molecular Weight | 220.225 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 520.6±50.0 °C at 760 mmHg |
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| Molecular Formula | C11H12N2O3 | Melting Point | 298-300ºC |
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| MSDS | / | Flash Point | 268.7±30.1 °C |
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Names
| Name | DL-5-Hydroxytryptophan |
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| Synonym | More Synonyms |
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5-Hydroxytryptophan BiologicalActivity
| Description | 5-Hydroxytryptophan, a tryptophan metabolite, is a direct 5-hydroxytryptamine (5-HT) precursor and an L-aromatic amino acid decarboxylase substrate. [1][2][3]. |
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| Related Catalog | Research Areas >>Metabolic Disease |
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| Target | Human Endogenous Metabolite |
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| References | [1]. Gartside SE, et al. Mediation of ACTH and prolactin responses to 5-HTP by 5-HT2 receptors. Eur J Pharmacol. 1990 Apr 10;179(1-2):103-9. [2]. Gijsman HJ, et al. Placebo-controlled comparison of three dose-regimens of 5-hydroxytryptophan challenge test in healthy volunteers. J Clin Psychopharmacol. 2002 Apr;22(2):183-9. [3]. Schruers K, et al. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients. Psychiatry Res. 2002 Dec 30;113(3):237-43. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 520.6±50.0 °C at 760 mmHg |
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| Melting Point | 298-300ºC |
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| Molecular Formula | C11H12N2O3 |
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| Molecular Weight | 220.225 |
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| Flash Point | 268.7±30.1 °C |
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| Exact Mass | 220.084793 |
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| PSA | 99.34000 |
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| LogP | -0.14 |
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| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
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| Index of Refraction | 1.737 |
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| InChIKey | LDCYZAJDBXYCGN-UHFFFAOYSA-N |
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| SMILES | NC(Cc1c[nH]c2ccc(O)cc12)C(=O)O |
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| Storage condition | 2-8°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- YN7000000
- CHEMICAL NAME :
- Tryptophan, 5-hydroxy-
- CAS REGISTRY NUMBER :
- 56-69-9
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C11-H12-N2-O3
- MOLECULAR WEIGHT :
- 220.25
- WISWESSER LINE NOTATION :
- T56 BMJ D1YZVQ GQ
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 30 mg/kg
- SEX/DURATION :
- male 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles)
- REFERENCE :
- ANENAG Annales d'Endocrinologie. (Masson Editeur, 120 Blvd. Saint-Germain, F-25280 Paris Cedex 06, France) V.1- 1939- Volume(issue)/page/year: 24(Suppl 3),1,1963 *** REVIEWS *** TOXICOLOGY REVIEW CLPTAT Clinical Pharmacology and Therapeutics (St. Louis). (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1960- Volume(issue)/page/year: 5,480,1964
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Safety Information
| Hazard Codes | Xn |
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| Risk Phrases | 22-36/37/38-65-20/21/22-20/21 |
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| Safety Phrases | 24/25-22 |
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| RIDADR | UN 2811 |
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| WGK Germany | 3.0 |
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| RTECS | YN7100000 |
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| Packaging Group | III |
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| HS Code | 2929909090 |
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Customs
| HS Code | 2929909090 |
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| Summary | 2929909090 other compounds with other nitrogen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
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Synonyms
| MFCD00005651 |
| 5-HYDROXY-TRYPTOPHAN |
| Tryptophan, 5-hydroxy-, DL- |
| 5-Hydroxytryptophan DL-form |
| DL-5-HTP |
| 2-Chloro-3-methylamine-5-trifluoromethylpyridine hydrochloride |
| Tryptophan, 5-hydroxy- |
| EINECS 200-284-8 |
| (±)-5-hydroxytryptophan |
| 5-Hydroxytryptophan |
| 5-Hydroxy Tryptophan |
| Dl-5-Hydroxytryptophan |
