CAS 56715-13-0|(R)-(+)-Atenolol

Introduction：Basic information about CAS 56715-13-0|(R)-(+)-Atenolol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. (R)-(+)-Atenolol BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Articles2
7. Synonyms

Common Name	(R)-(+)-Atenolol
CAS Number	56715-13-0	Molecular Weight	266.33600
Density	1.125g/cm3	Boiling Point	508ºC at 760mmHg
Molecular Formula	C₁₄H₂₂N₂O₃	Melting Point	148-152ºC(lit.)
MSDS	ChineseUSA	Flash Point	261.1ºC

Names

Name	(R)-atenolol
Synonym	More Synonyms

(R)-(+)-Atenolol BiologicalActivity

Description	(R)-(+)-Atenolol is the less active enantiomer of the (R,S)-atenolol. (R,S)-atenolol is a β-adrenergic receptor antagonist[1][2].
Related Catalog	Research Areas >>OthersSignaling Pathways >>Others >>Others
References	[1]. Batra S, et al. Bioassay, determination and separation of enantiomers of atenolol by direct and indirect approaches using liquid chromatography: A review. Biomed Chromatogr. 2018 Jan;32(1). [2]. Stoschitzky K, et al. Stereoselective features of (R)- and (S)-atenolol: clinical pharmacological, pharmacokinetic, and radioligand binding studies. Chirality. 1993;5(1):15-9.

Description

(R)-(+)-Atenolol is the less active enantiomer of the (R,S)-atenolol. (R,S)-atenolol is a β-adrenergic receptor antagonist[1][2].

Related Catalog

Research Areas >>OthersSignaling Pathways >>Others >>Others

References

[1]. Batra S, et al. Bioassay, determination and separation of enantiomers of atenolol by direct and indirect approaches using liquid chromatography: A review. Biomed Chromatogr. 2018 Jan;32(1).

[2]. Stoschitzky K, et al. Stereoselective features of (R)- and (S)-atenolol: clinical pharmacological, pharmacokinetic, and radioligand binding studies. Chirality. 1993;5(1):15-9.

Chemical & Physical Properties

Density	1.125g/cm3
Boiling Point	508ºC at 760mmHg
Melting Point	148-152ºC(lit.)
Molecular Formula	C₁₄H₂₂N₂O₃
Molecular Weight	266.33600
Flash Point	261.1ºC
Exact Mass	266.16300
PSA	84.58000
LogP	1.54330
Index of Refraction	1.54
InChIKey	METKIMKYRPQLGS-GFCCVEGCSA-N
SMILES	CC(C)NCC(O)COc1ccc(CC(N)=O)cc1

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
HS Code	2924299090

Customs

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles2

Effects of nebivolol on endothelial gene expression during oxidative stress in human umbilical vein endothelial cells.

Mediators Inflamm. 2008 , 367590, (2008)

The endothelium plays a key role in the development of atherogenesis and its inflammatory and proliferative status influences the progression of atherosclerosis. The aim of this study is to compare th...

Molecular Dynamics Simulation and NMR Investigation of the Association of the _-Blockers Atenolol and Propranolol with a Chiral Molecular Micelle.

Chem. Phys. 457 , 133-146, (2015)

Molecular dynamics simulations and NMR spectroscopy were used to compare the binding of two _-blocker drugs to the chiral molecular micelle poly-(sodium undecyl-(L)-leucine-valine). The molecular mice...

Synonyms

Prenormin

MFCD00074917

2-[4-[(2R)-2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetamide

Recommended......