Introduction：Basic information about CAS 62973-76-6|Azanidazole, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Azanidazole |
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| CAS Number | 62973-76-6 | Molecular Weight | 246.22500 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C10H10N6O2 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 4-[(E)-2-(1-methyl-5-nitroimidazol-2-yl)ethenyl]pyrimidin-2-amine |
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| Synonym | More Synonyms |
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Chemical & Physical Properties
| Molecular Formula | C10H10N6O2 |
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| Molecular Weight | 246.22500 |
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| Exact Mass | 246.08700 |
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| PSA | 116.17000 |
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| LogP | 1.32420 |
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| InChIKey | LHIALLMPKJMSIQ-NSCUHMNNSA-N |
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| SMILES | Cn1c([N+](=O)[O-])cnc1C=Cc1ccnc(N)n1 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- UV6261500
- CHEMICAL NAME :
- 2-Pyrimidinamine, 4-(2-(1-methyl-5-nitro-1H-imidazol-2-yl)ethenyl)-, (E)-
- CAS REGISTRY NUMBER :
- 62973-76-6
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C10-H10-N6-O2
- MOLECULAR WEIGHT :
- 246.26
- WISWESSER LINE NOTATION :
- T6N CNJ BZ D1U1- BT5N CNJ A1 ENW
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 7600 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia Behavioral - irritability
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 860 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia Behavioral - irritability
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5100 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia Behavioral - irritability
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 162 gm/kg/26W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - urine volume increased Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1430 mg/kg
- SEX/DURATION :
- female 6-18 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
MUTATION DATA - TYPE OF TEST :
- Host-mediated assay
- TEST SYSTEM :
- Rodent - mouse Yeast - Saccharomyces cerevisiae
- DOSE/DURATION :
- 25 mmol/kg
- REFERENCE :
- DECRDP Drugs under Experimental and Clinical Research. (Bioscience Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland) V.1- 1977- Volume(issue)/page/year: 11,755,1985
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Synonyms
| Nitromidine |
| 4-((E)-2-(1-Methyl-5-nitro-1H-imidazol-2-yl)-ethenyl)-2-pyrimidinamine |
| Triclose |
| Azanidazol |
| Azanidazole |
| Azanidazolum [INN-Latin] |
| (E)-2-Amino-4-(2-(1-methyl-5-nitroimidazol-2-yl)vinyl)pyrimidine |
| Azanidazol [INN-Spanish] |
| Azanidazolum |
