CAS 86770-68-5|Azido-PEG5-alcohol
Introduction：Basic information about CAS 86770-68-5|Azido-PEG5-alcohol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Azido-PEG5-alcohol | ||
|---|---|---|---|
| CAS Number | 86770-68-5 | Molecular Weight | 263.291 |
| Density | / | Boiling Point | / |
| Molecular Formula | C10H21N3O5 | Melting Point | / |
| MSDS | / | Flash Point | 100 °C |
Names
| Name | 14-Azido-3,6,9,12-tetraoxatetradecanol |
|---|---|
| Synonym | More Synonyms |
Azido-PEG5-alcohol BiologicalActivity
| Description | Azido-PEG5-alcohol is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG5-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC LinkerSignaling Pathways >>PROTAC >>PROTAC Linker |
| Target | PEGs Non-cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
| References | [1]. Zhang FL, et al. Molecular-target-based anticancer photosensitizer: synthesis and in vitro photodynamic activity of erlotinib-zinc(II) phthalocyanine conjugates. ChemMedChem. 2015 Feb;10(2):312-20. [2]. Nan JI, et al. Mertk degraders and uses thereof. WO2020010210A1. |
Chemical & Physical Properties
| Molecular Formula | C10H21N3O5 |
|---|---|
| Molecular Weight | 263.291 |
| Flash Point | 100 °C |
| Exact Mass | 263.148132 |
| PSA | 106.90000 |
| LogP | -1.59 |
| Index of Refraction | 1.47 |
| InChIKey | JTGGTGKXQQGEHB-UHFFFAOYSA-N |
| SMILES | [N-]=[N+]=NCCOCCOCCOCCOCCO |
Synonyms
| 3,6,9,12-Tetraoxatetradecan-1-ol, 14-azido- |
| 14-Azido-3,6,9,12-tetraoxatetradecan-1-ol |
| 2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethanol |
