CAS 501-97-3|Desaminotyrosine
Introduction：Basic information about CAS 501-97-3|Desaminotyrosine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Desaminotyrosine | ||
|---|---|---|---|
| CAS Number | 501-97-3 | Molecular Weight | 166.174 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 352.4±17.0 °C at 760 mmHg |
| Molecular Formula | C9H10O3 | Melting Point | 129-131 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 181.1±17.4 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | phloretic acid |
|---|---|
| Synonym | More Synonyms |
Desaminotyrosine BiologicalActivity
| Description | Desaminotyrosine is a microbially associated metabolite protecting from influenza through augmentation of type I interferon signaling. |
|---|---|
| Related Catalog | Signaling Pathways >>Anti-infection >>Influenza VirusResearch Areas >>InfectionNatural Products >>Saccharides and Glycosides |
| Target | Human Endogenous Metabolite |
| In Vivo | Wild-type mice produce nanomoles of Desaminotyrosine per gram of feces and have picomolar quantities of Desaminotyrosine in the serum. Desaminotyrosine (200 mM) treatment before influenza infection, protects from influenza by type I interferon (IFN) signaling, with no effect on weight loss or survival in mice with or without vancomycin, neomycin, ampicillin, and metronidazole (VNAM). Desaminotyrosine enhances type I IFN in macrophages via type I IFN amplification in mice[1]. |
| Animal Admin | Mice[1] Indicated mice receive 200 mM Desaminotyrosine dissolved in Kool-Aid in the drinking water (control animals receive Kool-Aid alone). Indicated mice receive poly(IC) injections of 1 mg/kg for vancomycin, neomycin, ampicillin, and metronidazole (VNAM) treated mice or 5 mg/kg for all other mice intraperitoneally daily for 4 days, and then mice are scarified on day five at which time serum is collected[1]. |
| References | [1]. Steed AL, et al. The microbial metabolite desaminotyrosine protects from influenza through type I interferon. Science. 2017 Aug 4;357(6350):498-502. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 352.4±17.0 °C at 760 mmHg |
| Melting Point | 129-131 °C(lit.) |
| Molecular Formula | C9H10O3 |
| Molecular Weight | 166.174 |
| Flash Point | 181.1±17.4 °C |
| Exact Mass | 166.062988 |
| PSA | 57.53000 |
| LogP | 1.10 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.580 |
| InChIKey | NMHMNPHRMNGLLB-UHFFFAOYSA-N |
| SMILES | O=C(O)CCc1ccc(O)cc1 |
| Storage condition | 2-8°C |
| Water Solubility | slightly soluble |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1809 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 12,265,1976
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi:Irritant |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36-S37/39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | MW5342000 |
| HS Code | 2916399090 |
Customs
| HS Code | 2918290000 |
|---|---|
| Summary | HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0% |
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Synonyms
| Benzenepropanoic acid, 4-hydroxy- |
| 4-hydroxy-benzenepropanoic acid |
| MFCD00002778 |
| 3-(p-hydroxyphenyl)propionic acid |
| 4-Hydroxyhydrocinnamic Acid |
| 3-(4-Hydroxyphenyl)propanoic acid |
| Phloretic acid |
| 3-(p-Hydroxyphenyl)propionic acid,Phloretic acid |
| 3-(para-Hydroxyphenyl)propionic acid |
| 3-(4-Hydroxyphenyl)-propionic acid |
| 3-(4-Hydroxyphenyl)propionic acid |
| b-(p-Hydroxyphenyl)propionic acid |
| p-hydroxy-hydrocinnamic acid |
| EINECS 207-931-3 |
