Introduction：Basic information about CAS 101-93-9|holocalin(p), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | holocalin(p) |
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| CAS Number | 101-93-9 | Molecular Weight | 298.37900 |
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| Density | 1.04g/cm3 | Boiling Point | 464.5ºC at 760mmHg |
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| Molecular Formula | C18H22N2O2 | Melting Point | 117°C |
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| MSDS | / | Flash Point | 234.7ºC |
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Names
| Name | N,N'-bis(4-ethoxyphenyl)ethanimidamide |
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| Synonym | More Synonyms |
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holocalin(p) BiologicalActivity
| Description | Phenacaine (Holocaine) is a local anesthetic. Phenacaine inhibits the specific calmodulin-dependent stimulation of erythrocyte Ca2+-ATPase and cyclic nucleotide phosphodiesterases from brain and heart[1][2]. |
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| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Phosphodiesterase (PDE)Research Areas >>Metabolic Disease |
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| In Vitro | Phenacaine inhibits the specific calmodulin-dependent stimulation of erythrocyte Ca2+-ATPase (EC 3.6.1.3) and cyclic nucleotide phosphodiesterase (EC 3.1.4.17) in brain and heart tissues[1]. Phenacaine (1 μM-1 mM) depresses glucose-induced insulin secretion by pancreas[2]. |
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Chemical & Physical Properties
| Density | 1.04g/cm3 |
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| Boiling Point | 464.5ºC at 760mmHg |
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| Melting Point | 117°C |
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| Molecular Formula | C18H22N2O2 |
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| Molecular Weight | 298.37900 |
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| Flash Point | 234.7ºC |
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| Exact Mass | 298.16800 |
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| PSA | 42.85000 |
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| LogP | 4.71900 |
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| Vapour Pressure | 8.29E-09mmHg at 25°C |
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| Index of Refraction | 1.534 |
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| InChIKey | QXDAEKSDNVPFJG-UHFFFAOYSA-N |
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| SMILES | CCOc1ccc(N=C(C)Nc2ccc(OCC)cc2)cc1 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- AD0350000
- CHEMICAL NAME :
- Acetamidine, N,N'-bis(p-ethoxyphenyl)-
- CAS REGISTRY NUMBER :
- 101-93-9
- BEILSTEIN REFERENCE NO. :
- 2702842
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C18-H22-N2-O2
- MOLECULAR WEIGHT :
- 298.42
- WISWESSER LINE NOTATION :
- 2OR DNUY1&MR DO2
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 10 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year: 12,190,1932
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 5 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year: 12,190,1932
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 53 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year: 12,190,1932
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 15 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year: 12,190,1932
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Safety Information
Customs
| HS Code | 2925290090 |
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| Summary | 2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
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Synonyms
| Fenacaine |
| Holocaine |
| Phenacaine |
| Tanicaine |
