CAS 23749-58-8|7H-Benzimidazo[2,1-a]benzo[de]isoquinolin-7-one

[1]. Elson DJ, et.al. Induction of Aryl Hydrocarbon Receptor-Mediated Cancer Cell-Selective Apoptosis in Triple-Negative Breast Cancer Cells by a High-Affinity Benzimidazoisoquinoline. ACS Pharmacol Transl Sci. 2023 Jun 7;6(7):1028-1042.  

CHEMICAL IDENTIFICATION

RTECS NUMBER :

DD5380000

CHEMICAL NAME :

7H-Benzimidazo(2,1-a)benz(de)isoquinolin-7-one

CAS REGISTRY NUMBER :

23749-58-8

BEILSTEIN REFERENCE NO. :

0243687

LAST UPDATED :

199709

DATA ITEMS CITED :

2

MOLECULAR FORMULA :

C18-H10-N2-O

MOLECULAR WEIGHT :

270.30

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

660 mg/kg

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - hemorrhage Behavioral - muscle weakness Gastrointestinal - other changes

REFERENCE :

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),89,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

15 gm/kg/30D-I

TOXIC EFFECTS :

Liver - liver function tests impaired Kidney, Ureter, Bladder - other changes Related to Chronic Data - death

REFERENCE :

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),89,1986