Introduction：Basic information about CAS 6981-18-6|Ormetoprim, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ormetoprim |
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| CAS Number | 6981-18-6 | Molecular Weight | 274.318 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 398.2±52.0 °C at 760 mmHg |
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| Molecular Formula | C14H18N4O2 | Melting Point | 233°C |
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| MSDS | / | Flash Point | 194.6±30.7 °C |
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Names
| Name | 5-[(4,5-dimethoxy-2-methylphenyl)methyl]pyrimidine-2,4-diamine |
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| Synonym | More Synonyms |
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Ormetoprim BiologicalActivity
| Description | Ormetoprim is a veterinary antimicrobial which commonly used in aquaculture and poultry industries. Ormetoprim can be used to prevent the spread of disease in freshwater aquaculture and promote growth in farm animals[1][2]. |
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| Related Catalog | Research Areas >>Infection |
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| In Vivo | Ormetoprim (8.3 mg/kg; i.p.) exhibits absorption half-life (5.4 h), elimination half-life (7.5 h) and Cmax (1.2±0.2 μg/mL)[3]. Ormetoprim (8.3 mg/kg; p.o.) exhibits absorption half-life (3.9 h), elimination half-life (3.9 h), Cmax (1.6±0.4 μg/mL) and oral availability (78.5%) relative to intraperitoneal administration[3]. Animal Model: Hybrid striped bass (565-805 g)[3] Dosage: 50 mg/kg Sulfadimethoxine and Ormetoprim in a 5:1 ratio (Pharmacokinetic Analysis) Administration: I.p. and p.o. administration Result: I.p.: t1/2(elim)=7.5 h; t1/2(abs)=5.4 h; Cmax=1.2 μg/mL. P.o.: t1/2(elim)=3.9 h; t1/2(abs)=3.9 h; Cmax=1.6 μg/mL; F=78.5%. |
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| References | [1]. Sanders SM, et, al. Sorption of the veterinary antimicrobials sulfadimethoxine and ormetoprim in soil. J Environ Qual. 2008 Jun 23; 37(4): 1510-8. [2]. Guerard JJ, et, al. Photodegradation of ormetoprim in aquaculture and stream-derived dissolved organic matter. J Agric Food Chem. 2012 Oct 3; 60(39): 9801-6. [3]. Bakal RS, et, al. Pharmacokinetics of sulfadimethoxine and ormetoprim in a 5:1 ratio following intraperitoneal and oral administration, in the hybrid striped bass (Morone chrysops x Morone saxitalis). J Vet Pharmacol Ther. 2004 Feb; 27(1): 1-6. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 398.2±52.0 °C at 760 mmHg |
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| Melting Point | 233°C |
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| Molecular Formula | C14H18N4O2 |
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| Molecular Weight | 274.318 |
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| Flash Point | 194.6±30.7 °C |
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| Exact Mass | 274.142975 |
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| PSA | 96.28000 |
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| LogP | 1.13 |
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| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
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| Index of Refraction | 1.608 |
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| InChIKey | KEEYRKYKLYARHO-UHFFFAOYSA-N |
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| SMILES | COc1cc(C)c(Cc2cnc(N)nc2N)cc1OC |
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| Storage condition | 0-6°C |
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Synonyms
| UNII-M3EFS94984 |
| 5-((4,5-Dimethoxy-2-methylphenyl)methyl)-2,4-pyrimidinediamine |
| Ro 5-9754 |
| component of Rofenaid |
| Ormetoprim |
| EINECS 230-246-6 |
| MFCD00057747 |
| 2,4-Pyrimidinediamine, 5-[(4,5-dimethoxy-2-methylphenyl)methyl]- |
| 5-(4,5-Dimethoxy-2-methylbenzyl)-2,4(1H,3H)-pyrimidinediimine |
| 5-(4,5-Dimethoxy-2-methylbenzyl)pyrimidine-2,4-diamine |
| 2,4(1H,3H)-Pyrimidinediimine, 5-[(4,5-dimethoxy-2-methylphenyl)methyl]- |
| 5-(4,5-Dimethoxy-2-methylbenzyl)-2,4-pyrimidinediamine |
| Ormethoprim |
| Ormetorprim |
