CAS 27025-41-8|L(-)-Glutathione

Introduction：Basic information about CAS 27025-41-8|L(-)-Glutathione, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameL(-)-Glutathione
CAS Number27025-41-8Molecular Weight612.631
Density1.7±0.1 g/cm3Boiling Point976.3±75.0 °C at 760 mmHg
Molecular FormulaC20H32N6O12S2Melting Point178 °C (dec.)(lit.)
MSDSUSAFlash Point544.3±37.1 °C

Names

Nameglutathione disulfide
SynonymMore Synonyms

L(-)-Glutathione BiologicalActivity

DescriptionGlutathione oxidized is produced by the oxidation of glutathione which is a major intracellular antioxidant and detoxifying agent.
Related CatalogResearch Areas >>Metabolic DiseaseNatural Products >>Others
Target

Human Endogenous Metabolite

References

[1]. Nur E, et al. Increased efflux of oxidized glutathione (GSSG) causes glutathione depletion and potentially diminishes antioxidant defense in sickle erythrocytes. Biochim Biophys Acta. 2011 Nov;1812(11):1412-7.

Chemical & Physical Properties

Density1.7±0.1 g/cm3
Boiling Point976.3±75.0 °C at 760 mmHg
Melting Point178 °C (dec.)(lit.)
Molecular FormulaC20H32N6O12S2
Molecular Weight612.631
Flash Point544.3±37.1 °C
Exact Mass612.151978
PSA368.24000
LogP1.91
Vapour Pressure0.0±0.6 mmHg at 25°C
Index of Refraction1.677
InChIKeyYPZRWBKMTBYPTK-BJDJZHNGSA-N
SMILES[NH3+]C(CCC(=O)NC(CSSCC(NC(=O)CCC([NH3+])C(=O)[O-])C(=O)NCC(=O)O)C(=O)NCC(=O)O)C(=O)[O-]
Storage condition2~8°C
Water Solubilitysoluble

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MC0556500
CHEMICAL NAME :
Glycine, L-gamma-glutamyl-L-cysteinyl-, (2,2')-disulfide
CAS REGISTRY NUMBER :
27025-41-8
LAST UPDATED :
199212
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C20-H32-N6-O12-S2
MOLECULAR WEIGHT :
612.70

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 23,6793,1989
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 23,6793,1989
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 23,6793,1989
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 23,6793,1989
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 23,6793,1989
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 23,6793,1989

Safety Information

Personal Protective EquipmentEyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard CodesXi: Irritant;
Risk PhrasesR36/37/38
Safety PhrasesS26-S36-S24/25
RIDADRNONH for all modes of transport
WGK Germany2
RTECSMC0556500

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Synonyms

Glutathione disulfide
Glutathione (oxidized form)
GSSG,Glutathiol
Glutathiol,GSSG
L-Glutathione oxidized
(2S,5Z,2'S,5'E)-5,5'-[Disulfanediylbis({(2R,3Z)-3-[(carboxymethyl)imino]-3-hydroxy-1,2-propanediyl}nitrilo)]bis(2-amino-5-hydroxypentanoic acid) (non-preferred name)
oxigluthione
glutathonedisulfide
glutathione-ssg
Oxiglutatione
GSH disulfide
GSSC
MFCD00063106
N,N'-(Dithiobis(1-((carboxymethyl)carbamoyl)ethylene))di-L-glutamine
GSSG
N-(N-g-Glutamyl-cysteinyl)glycine-(2,2)-disulfide
L(-)-Glutathione
Glutathiol
Oxyglutatione
(2S,2'S)-5,5'-[Disulfanediylbis({(2R)-3-[(carboxymethyl)amino]-3-oxo-1,2-propanediyl}imino)]bis(2-amino-5-oxopentanoic acid)
glutathione oxidized
EINECS 248-170-7
glutathione oxidized form
Oxidized glutathione
GSSG oxidized form
(2S,2'S)-5,5'-[Disulfanediylbis({(2R)-3-[(carboxymethyl)amino]-3-oxopropane-1,2-diyl}imino)]bis(2-amino-5-oxopentanoic acid) (non-preferred name)
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